B-Type Natriuretic Peptide

Beyond a Diagnostic

Fernando L. Martin, Horng Haur Chen, Alessandro Cataliotti, John C Jr. Burnett

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The concept of the heart as an endocrine organ has been attractive since the discovery of atrial natriuretic peptide. This review focuses on the second discovered natriuretic peptide from the heart-B-type natriuretic peptide (BNP), widely used as a tool in the diagnosis of heart failure (HF). Controversy remains regarding its use as a therapeutic agent in HF. This article places into perspective some of the debate and provides insights into the therapeutics of BNP and the importance of its second messenger 3′5′ cyclic guanosine monophosphate, which also is the second messenger for nitric oxide and is modulated by renal phosphodiesterases.

Original languageEnglish (US)
Pages (from-to)449-454
Number of pages6
JournalHeart Failure Clinics
Volume4
Issue number4
DOIs
StatePublished - Oct 2008

Fingerprint

Brain Natriuretic Peptide
Second Messenger Systems
Heart Failure
Natriuretic Peptides
Cyclic GMP
Phosphoric Diester Hydrolases
Atrial Natriuretic Factor
Nitric Oxide
Kidney
Therapeutics
peptide B

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

B-Type Natriuretic Peptide : Beyond a Diagnostic. / Martin, Fernando L.; Chen, Horng Haur; Cataliotti, Alessandro; Burnett, John C Jr.

In: Heart Failure Clinics, Vol. 4, No. 4, 10.2008, p. 449-454.

Research output: Contribution to journalArticle

Martin, Fernando L. ; Chen, Horng Haur ; Cataliotti, Alessandro ; Burnett, John C Jr. / B-Type Natriuretic Peptide : Beyond a Diagnostic. In: Heart Failure Clinics. 2008 ; Vol. 4, No. 4. pp. 449-454.
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