B-Type Natriuretic Peptide: Beyond a Diagnostic

Fernando L. Martin; Horng H. Chen; Alessandro Cataliotti; John C. Burnett

doi:10.1016/j.hfc.2008.03.011

B-Type Natriuretic Peptide: Beyond a Diagnostic

Fernando L. Martin, Horng H. Chen, Alessandro Cataliotti, John C. Burnett

Cardiovascular Medicine

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

The concept of the heart as an endocrine organ has been attractive since the discovery of atrial natriuretic peptide. This review focuses on the second discovered natriuretic peptide from the heart-B-type natriuretic peptide (BNP), widely used as a tool in the diagnosis of heart failure (HF). Controversy remains regarding its use as a therapeutic agent in HF. This article places into perspective some of the debate and provides insights into the therapeutics of BNP and the importance of its second messenger 3′5′ cyclic guanosine monophosphate, which also is the second messenger for nitric oxide and is modulated by renal phosphodiesterases.

Original language	English (US)
Pages (from-to)	449-454
Number of pages	6
Journal	Heart Failure Clinics
Volume	4
Issue number	4
DOIs	https://doi.org/10.1016/j.hfc.2008.03.011
State	Published - Oct 2008

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.hfc.2008.03.011

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title = "B-Type Natriuretic Peptide: Beyond a Diagnostic",

abstract = "The concept of the heart as an endocrine organ has been attractive since the discovery of atrial natriuretic peptide. This review focuses on the second discovered natriuretic peptide from the heart-B-type natriuretic peptide (BNP), widely used as a tool in the diagnosis of heart failure (HF). Controversy remains regarding its use as a therapeutic agent in HF. This article places into perspective some of the debate and provides insights into the therapeutics of BNP and the importance of its second messenger 3′5′ cyclic guanosine monophosphate, which also is the second messenger for nitric oxide and is modulated by renal phosphodiesterases.",

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T2 - Beyond a Diagnostic

AU - Martin, Fernando L.

AU - Chen, Horng H.

AU - Cataliotti, Alessandro

AU - Burnett, John C.

PY - 2008/10

Y1 - 2008/10

N2 - The concept of the heart as an endocrine organ has been attractive since the discovery of atrial natriuretic peptide. This review focuses on the second discovered natriuretic peptide from the heart-B-type natriuretic peptide (BNP), widely used as a tool in the diagnosis of heart failure (HF). Controversy remains regarding its use as a therapeutic agent in HF. This article places into perspective some of the debate and provides insights into the therapeutics of BNP and the importance of its second messenger 3′5′ cyclic guanosine monophosphate, which also is the second messenger for nitric oxide and is modulated by renal phosphodiesterases.

AB - The concept of the heart as an endocrine organ has been attractive since the discovery of atrial natriuretic peptide. This review focuses on the second discovered natriuretic peptide from the heart-B-type natriuretic peptide (BNP), widely used as a tool in the diagnosis of heart failure (HF). Controversy remains regarding its use as a therapeutic agent in HF. This article places into perspective some of the debate and provides insights into the therapeutics of BNP and the importance of its second messenger 3′5′ cyclic guanosine monophosphate, which also is the second messenger for nitric oxide and is modulated by renal phosphodiesterases.

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B-Type Natriuretic Peptide: Beyond a Diagnostic

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