B-lymphoblastic leukemia/lymphoma associated with t(8;13)(p11;q12)/ZMYM2 (ZNF198)-FGFR1: Rare case and review of the literature

Janese Trimaldi, Estrella M. Carballido, Jeremy W. Bowers, Arturo L. Anguiano, Zhong J. Zhang, Bijal D. Shah, Salvador Bruno, Alan F. List, Lynn C. Moscinski, Terrence Grady, Steven J. Agosti, Loveleen Kang, Ling Zhang

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Myeloid and lymphoid neoplasms with fibroblastic growth factor receptor-1 (FGFR1) abnormalities originate from mutated pluripotent stem cells and have a heterogeneous clinical presentation. There are 12 identified partner genes commonly involved in FGFR1 translocation at an 8p11 breakpoint. In FGFR1-related neoplasms, T-lymphoblastic lymphoma with eosinophilia is the most common clinical scenario, whereas acute B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) is rare. To date, only 7 cases of B-ALL/LBL with FGFR1 abnormalities have been reported. Here, we report an additional case of a 64-year-old gentleman with leukocytosis, eosinophilia and diffuse mediastinal and general lymphadenopathy. Bone marrow examination showed patchy infiltrates of immature precursors/blasts, along with myeloid/eosinophilic hyperplasia. Immunophenotyping confirmed increased B lymphoblasts (30-40%). Karyotyping revealed cytogenetic abnormalities, including t(8;13)(p11;q12)/ZMYM2 (ZNF198)-FGFR1 and trisomy 21. The patient did not respond to hyper-CVAD chemotherapy and within 4 months developed acute myelomonocytic leukemia and expired 11 months after the initial diagnosis. Similar cases from the literature are reviewed.

Original languageEnglish (US)
Pages (from-to)127-134
Number of pages8
JournalActa Haematologica
Volume130
Issue number3
DOIs
StatePublished - Jan 1 2013

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Keywords

  • 8p11
  • Acute B-lymphoblastic leukemia/lymphoma
  • t(8;13)(p11;q12)/ZMYM2 (ZNF198)-FGFR1

ASJC Scopus subject areas

  • Hematology

Cite this

Trimaldi, J., Carballido, E. M., Bowers, J. W., Anguiano, A. L., Zhang, Z. J., Shah, B. D., Bruno, S., List, A. F., Moscinski, L. C., Grady, T., Agosti, S. J., Kang, L., & Zhang, L. (2013). B-lymphoblastic leukemia/lymphoma associated with t(8;13)(p11;q12)/ZMYM2 (ZNF198)-FGFR1: Rare case and review of the literature. Acta Haematologica, 130(3), 127-134. https://doi.org/10.1159/000347030