B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/Smad signaling

Sean S Park, Jae Lee Young, Ho Jae Lee, Tsugio Seki, Kwon Ho Hong, Joonil Park, Hideyuki Beppu, Kyung Lim In, Ji Won Yoon, En Li, Seong Jin Kim, S. Paul Oh

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Btg2 is a primary p53 transcriptional target gene which may function as a coactivator-corepressor and/or an adaptor molecule that modulates the activities of its interacting proteins. We have generated Btg2-null mice to elucidate the in vivo function of Btg2. Btg2-null mice are viable and fertile but exhibit posterior homeotic transformations of the axial vertebrae in a dose-dependent manner. Consistent with its role in vertebral patterning, Btg2 is expressed in the presomitic mesoderm, tail bud, and somites during somitogenesis. We further provide biochemical evidence that Btg2 interacts with bone morphogenetic protein (BMP)-activated Smads and enhances the transcriptional activity of BMP signaling. In view of the genetic evidence that reduced BMP signaling causes posteriorization of the vertebral pattern, we propose that the observed vertebral phenotype in Btg2-null mice is due to attenuated BMP signaling.

Original languageEnglish (US)
Pages (from-to)10256-10262
Number of pages7
JournalMolecular and Cellular Biology
Volume24
Issue number23
DOIs
StatePublished - Dec 2004
Externally publishedYes

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Bone Morphogenetic Proteins
B-Lymphocytes
Genes
Co-Repressor Proteins
Somites
Mesoderm
Tail
Spine
Phenotype

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/Smad signaling. / Park, Sean S; Young, Jae Lee; Lee, Ho Jae; Seki, Tsugio; Hong, Kwon Ho; Park, Joonil; Beppu, Hideyuki; In, Kyung Lim; Yoon, Ji Won; Li, En; Kim, Seong Jin; Oh, S. Paul.

In: Molecular and Cellular Biology, Vol. 24, No. 23, 12.2004, p. 10256-10262.

Research output: Contribution to journalArticle

Park, SS, Young, JL, Lee, HJ, Seki, T, Hong, KH, Park, J, Beppu, H, In, KL, Yoon, JW, Li, E, Kim, SJ & Oh, SP 2004, 'B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/Smad signaling', Molecular and Cellular Biology, vol. 24, no. 23, pp. 10256-10262. https://doi.org/10.1128/MCB.24.23.10256-10262.2004
Park, Sean S ; Young, Jae Lee ; Lee, Ho Jae ; Seki, Tsugio ; Hong, Kwon Ho ; Park, Joonil ; Beppu, Hideyuki ; In, Kyung Lim ; Yoon, Ji Won ; Li, En ; Kim, Seong Jin ; Oh, S. Paul. / B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/Smad signaling. In: Molecular and Cellular Biology. 2004 ; Vol. 24, No. 23. pp. 10256-10262.
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AU - Park, Joonil

AU - Beppu, Hideyuki

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AU - Kim, Seong Jin

AU - Oh, S. Paul

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