B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/Smad signaling

Sean Park, Jae Lee Young, Ho Jae Lee, Tsugio Seki, Kwon Ho Hong, Joonil Park, Hideyuki Beppu, Kyung Lim In, Ji Won Yoon, En Li, Seong Jin Kim, S. Paul Oh

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Btg2 is a primary p53 transcriptional target gene which may function as a coactivator-corepressor and/or an adaptor molecule that modulates the activities of its interacting proteins. We have generated Btg2-null mice to elucidate the in vivo function of Btg2. Btg2-null mice are viable and fertile but exhibit posterior homeotic transformations of the axial vertebrae in a dose-dependent manner. Consistent with its role in vertebral patterning, Btg2 is expressed in the presomitic mesoderm, tail bud, and somites during somitogenesis. We further provide biochemical evidence that Btg2 interacts with bone morphogenetic protein (BMP)-activated Smads and enhances the transcriptional activity of BMP signaling. In view of the genetic evidence that reduced BMP signaling causes posteriorization of the vertebral pattern, we propose that the observed vertebral phenotype in Btg2-null mice is due to attenuated BMP signaling.

Original languageEnglish (US)
Pages (from-to)10256-10262
Number of pages7
JournalMolecular and cellular biology
Volume24
Issue number23
DOIs
StatePublished - Dec 2004

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/Smad signaling'. Together they form a unique fingerprint.

  • Cite this

    Park, S., Young, J. L., Lee, H. J., Seki, T., Hong, K. H., Park, J., Beppu, H., In, K. L., Yoon, J. W., Li, E., Kim, S. J., & Oh, S. P. (2004). B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/Smad signaling. Molecular and cellular biology, 24(23), 10256-10262. https://doi.org/10.1128/MCB.24.23.10256-10262.2004