Axonal transport of dopamine-β-hydroxylase by human sural nerves in vitro

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Abstract

Dopamine-β-hydroxylase activity accumulated above a ligature on biopsy samples of normal human sural nerves incubated in vitro. The rate of accumulation indicated that this enzyme was transported distally at a velocity of 2 millimeters per hour. Axoplasmic transport of dopamine-β-hydroxylase was greatly reduced in sural nerves from a few patients with peripheral neuropathies.

Original languageEnglish (US)
Pages (from-to)1295-1297
Number of pages3
JournalScience
Volume180
Issue number4092
DOIs
StatePublished - Jan 1 1973

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