Axonal transport in neuropathy

J. Jakobsen, William Stephen Brimijoin, P. Sidenius

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Recent studies on the distribution of labeled endogenous proteins in the experimental neuropathies induced by streptozotocin diabetes, galactose feeding, zinc pyridinethione, 2,5-hexanedione, acrylamide, and p-bromophenylacetylurea (BPAU) have demonstrated an impaired build up of retrogradely transported material derived from the more distal parts of peripheral nerve. In BPAU neuropathy the transport abnormality is strongly related to the degree of muscle weakness; following treatment with acrylamide the extent of the impairment is dose related. In both toxic conditions the transport abnormality is present well in advance of the first clinical signs of neuropathy. We therefore suggest that changes in the retrograde axonal transport play an initial and important role in the development of many axonopathies.

Original languageEnglish (US)
Pages (from-to)164-166
Number of pages3
JournalMuscle and Nerve
Volume6
Issue number2
StatePublished - 1983

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Axonal Transport
Acrylamide
Experimental Diabetes Mellitus
Poisons
Muscle Weakness
Galactose
Peripheral Nerves
Proteins
pyrithione zinc
2,5-hexanedione
4-bromophenylacetylurea

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Jakobsen, J., Brimijoin, W. S., & Sidenius, P. (1983). Axonal transport in neuropathy. Muscle and Nerve, 6(2), 164-166.

Axonal transport in neuropathy. / Jakobsen, J.; Brimijoin, William Stephen; Sidenius, P.

In: Muscle and Nerve, Vol. 6, No. 2, 1983, p. 164-166.

Research output: Contribution to journalArticle

Jakobsen, J, Brimijoin, WS & Sidenius, P 1983, 'Axonal transport in neuropathy', Muscle and Nerve, vol. 6, no. 2, pp. 164-166.
Jakobsen J, Brimijoin WS, Sidenius P. Axonal transport in neuropathy. Muscle and Nerve. 1983;6(2):164-166.
Jakobsen, J. ; Brimijoin, William Stephen ; Sidenius, P. / Axonal transport in neuropathy. In: Muscle and Nerve. 1983 ; Vol. 6, No. 2. pp. 164-166.
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