Axonal caliber and neurofilaments are proportionately decreased in galactose neuropathy

H. Nukada, Peter J Dyck, Phillip Anson Low, A. C. Lais, M. F. Sparks

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Feeding galactose to rats induces nerve conduction abnormalities, increased levels of nerve galactitol, endoneurial edema, elevated pressure and hypoxia of endoneurial fluid, and pathological abnormalities of nerve fibers. To investigate the cellular mechanisms of the fiber lesions and their possible relationship to alterations in the nerve microenvironment, rat peroneal nerves were morphometrically evaluated eight months after the commencement of galactose feeding. Whereas the desity of neurofilaments (NF/μm2) in the transverse axonal area of myelinated fibers was not significantly different between the nerves of galactose-fed and control rats, axonal areas and the number of NF/axon, when related to myelin spiral length, were significantly less in nerves of galactose-fed rats. Myelin alterations, characteristics of axonal atrophy, were also significantly increased. The present data provide evidence of a proportionate decrease in axonal caliber and the number of NF/axon in myelinated fibers in experimental galactose neropathy, suggesting that galactose induces either decreased NF synthesis, assembly or transport. The possible role of microenvironmental alterations, including endoneurial hypoxia and hypersmolarity, in the production of this axonal atrophy is discussed.

Original languageEnglish (US)
Pages (from-to)140-150
Number of pages11
JournalJournal of Neuropathology and Experimental Neurology
Volume45
Issue number2
StatePublished - 1986

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Intermediate Filaments
Galactose
Myelin Sheath
Atrophy
Axons
Galactitol
Peroneal Nerve
Neural Conduction
Nerve Fibers
Edema
Pressure

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Axonal caliber and neurofilaments are proportionately decreased in galactose neuropathy. / Nukada, H.; Dyck, Peter J; Low, Phillip Anson; Lais, A. C.; Sparks, M. F.

In: Journal of Neuropathology and Experimental Neurology, Vol. 45, No. 2, 1986, p. 140-150.

Research output: Contribution to journalArticle

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