Awake craniotomy vs craniotomy under general anesthesia for perirolandic gliomas: Evaluating perioperative complications and extent of resection

Chikezie I. Eseonu, Jordina Rincon-Torroella, Karim ReFaey, Young M. Lee, Jasvinder Nangiana, Tito Vivas-Buitrago, Alfredo Quinones-Hinojosa

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

BACKGROUND: A craniotomy with direct cortical/subcortical stimulation either awake or under general anesthesia (GA) present 2 approaches for removing eloquent region tumors. With a reported higher prevalence of intraoperative seizures occurring during awake resections of perirolandic lesions, oftentimes, surgery under GA is chosen for these lesions. OBJECTIVE: To evaluate a single-surgeon’s experience with awake craniotomies (AC) vs surgery under GA for resecting perirolandic, eloquent, motor-region gliomas. METHODS: Between 2005 and 2015, a retrospective analysis of 27 patients with perirolandic, eloquent, motor-area gliomas that underwent an AC were case-control matched with 31 patients who underwent surgery under GA for gliomas in the same location. All patients underwent direct brain stimulation with neuromonitoring and perioperative risk factors, extent of resection, complications, and discharge status were assessed. RESULTS: The postoperative Karnofsky Performance Score (KPS) was significantly lower for the GA patients at 81.1 compared to the AC patients at 93.3 (P= .040). The extent of resection for GA patients was 79.6% while the AC patients had an 86.3% resection (P = .136). There were significantly more 100% total resections in the AC patients 25.9% compared to the GA group (6.5%; P= .041). Patients in the GA group had a longer mean length of hospitalization of 7.9 days compared to the AC group at 4.2 days (P = .049). CONCLUSION: We show that AC can be performed with more frequent total resections, better postoperative KPS, shorter hospitalizations, as well as similar perioperative complication rates compared to surgery under GA for perirolandic, eloquent motor-region glioma.

Original languageEnglish (US)
Pages (from-to)481-489
Number of pages9
JournalClinical Neurosurgery
Volume81
Issue number3
DOIs
StatePublished - Sep 1 2017
Externally publishedYes

Fingerprint

Craniotomy
Glioma
General Anesthesia
Hospitalization
Motor Cortex
Seizures
Brain

Keywords

  • Anesthesia
  • Awake craniotomy
  • Cortical stimulation mapping
  • Glioblastoma
  • Glioma

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Awake craniotomy vs craniotomy under general anesthesia for perirolandic gliomas : Evaluating perioperative complications and extent of resection. / Eseonu, Chikezie I.; Rincon-Torroella, Jordina; ReFaey, Karim; Lee, Young M.; Nangiana, Jasvinder; Vivas-Buitrago, Tito; Quinones-Hinojosa, Alfredo.

In: Clinical Neurosurgery, Vol. 81, No. 3, 01.09.2017, p. 481-489.

Research output: Contribution to journalArticle

Eseonu, Chikezie I. ; Rincon-Torroella, Jordina ; ReFaey, Karim ; Lee, Young M. ; Nangiana, Jasvinder ; Vivas-Buitrago, Tito ; Quinones-Hinojosa, Alfredo. / Awake craniotomy vs craniotomy under general anesthesia for perirolandic gliomas : Evaluating perioperative complications and extent of resection. In: Clinical Neurosurgery. 2017 ; Vol. 81, No. 3. pp. 481-489.
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abstract = "BACKGROUND: A craniotomy with direct cortical/subcortical stimulation either awake or under general anesthesia (GA) present 2 approaches for removing eloquent region tumors. With a reported higher prevalence of intraoperative seizures occurring during awake resections of perirolandic lesions, oftentimes, surgery under GA is chosen for these lesions. OBJECTIVE: To evaluate a single-surgeon’s experience with awake craniotomies (AC) vs surgery under GA for resecting perirolandic, eloquent, motor-region gliomas. METHODS: Between 2005 and 2015, a retrospective analysis of 27 patients with perirolandic, eloquent, motor-area gliomas that underwent an AC were case-control matched with 31 patients who underwent surgery under GA for gliomas in the same location. All patients underwent direct brain stimulation with neuromonitoring and perioperative risk factors, extent of resection, complications, and discharge status were assessed. RESULTS: The postoperative Karnofsky Performance Score (KPS) was significantly lower for the GA patients at 81.1 compared to the AC patients at 93.3 (P= .040). The extent of resection for GA patients was 79.6{\%} while the AC patients had an 86.3{\%} resection (P = .136). There were significantly more 100{\%} total resections in the AC patients 25.9{\%} compared to the GA group (6.5{\%}; P= .041). Patients in the GA group had a longer mean length of hospitalization of 7.9 days compared to the AC group at 4.2 days (P = .049). CONCLUSION: We show that AC can be performed with more frequent total resections, better postoperative KPS, shorter hospitalizations, as well as similar perioperative complication rates compared to surgery under GA for perirolandic, eloquent motor-region glioma.",
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T1 - Awake craniotomy vs craniotomy under general anesthesia for perirolandic gliomas

T2 - Evaluating perioperative complications and extent of resection

AU - Eseonu, Chikezie I.

AU - Rincon-Torroella, Jordina

AU - ReFaey, Karim

AU - Lee, Young M.

AU - Nangiana, Jasvinder

AU - Vivas-Buitrago, Tito

AU - Quinones-Hinojosa, Alfredo

PY - 2017/9/1

Y1 - 2017/9/1

N2 - BACKGROUND: A craniotomy with direct cortical/subcortical stimulation either awake or under general anesthesia (GA) present 2 approaches for removing eloquent region tumors. With a reported higher prevalence of intraoperative seizures occurring during awake resections of perirolandic lesions, oftentimes, surgery under GA is chosen for these lesions. OBJECTIVE: To evaluate a single-surgeon’s experience with awake craniotomies (AC) vs surgery under GA for resecting perirolandic, eloquent, motor-region gliomas. METHODS: Between 2005 and 2015, a retrospective analysis of 27 patients with perirolandic, eloquent, motor-area gliomas that underwent an AC were case-control matched with 31 patients who underwent surgery under GA for gliomas in the same location. All patients underwent direct brain stimulation with neuromonitoring and perioperative risk factors, extent of resection, complications, and discharge status were assessed. RESULTS: The postoperative Karnofsky Performance Score (KPS) was significantly lower for the GA patients at 81.1 compared to the AC patients at 93.3 (P= .040). The extent of resection for GA patients was 79.6% while the AC patients had an 86.3% resection (P = .136). There were significantly more 100% total resections in the AC patients 25.9% compared to the GA group (6.5%; P= .041). Patients in the GA group had a longer mean length of hospitalization of 7.9 days compared to the AC group at 4.2 days (P = .049). CONCLUSION: We show that AC can be performed with more frequent total resections, better postoperative KPS, shorter hospitalizations, as well as similar perioperative complication rates compared to surgery under GA for perirolandic, eloquent motor-region glioma.

AB - BACKGROUND: A craniotomy with direct cortical/subcortical stimulation either awake or under general anesthesia (GA) present 2 approaches for removing eloquent region tumors. With a reported higher prevalence of intraoperative seizures occurring during awake resections of perirolandic lesions, oftentimes, surgery under GA is chosen for these lesions. OBJECTIVE: To evaluate a single-surgeon’s experience with awake craniotomies (AC) vs surgery under GA for resecting perirolandic, eloquent, motor-region gliomas. METHODS: Between 2005 and 2015, a retrospective analysis of 27 patients with perirolandic, eloquent, motor-area gliomas that underwent an AC were case-control matched with 31 patients who underwent surgery under GA for gliomas in the same location. All patients underwent direct brain stimulation with neuromonitoring and perioperative risk factors, extent of resection, complications, and discharge status were assessed. RESULTS: The postoperative Karnofsky Performance Score (KPS) was significantly lower for the GA patients at 81.1 compared to the AC patients at 93.3 (P= .040). The extent of resection for GA patients was 79.6% while the AC patients had an 86.3% resection (P = .136). There were significantly more 100% total resections in the AC patients 25.9% compared to the GA group (6.5%; P= .041). Patients in the GA group had a longer mean length of hospitalization of 7.9 days compared to the AC group at 4.2 days (P = .049). CONCLUSION: We show that AC can be performed with more frequent total resections, better postoperative KPS, shorter hospitalizations, as well as similar perioperative complication rates compared to surgery under GA for perirolandic, eloquent motor-region glioma.

KW - Anesthesia

KW - Awake craniotomy

KW - Cortical stimulation mapping

KW - Glioblastoma

KW - Glioma

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