Abstract
Objective: To report early diagnosis of a uterine leiomyosarcoma during screening for magnetic resonance imaging-guided focused ultrasound surgery (MRgFUS) for leiomyomas. Design: Case report. Setting: University hospital conducting an institutional review board-approved clinical trial. Patient(s): A 47-year-old premenopausal woman with presumed symptomatic leiomyomas for 5 years and minimal interval growth. Intervention(s): Magnetic resonance imaging screening protocol used as a routine part of MRgFUS treatment protocol. Main Outcome Measure(s): Surgical pathology report. Result(s): The diagnosis of leiomyosarcoma was suspected at the time of screening, and inadvertent treatment of a leiomyosarcoma was avoided. The patient underwent hysterectomy performed by her referring physician and confirmed the diagnosis of leiomyosarcoma. Conclusion(s): The possibility of inadvertent treatment of malignant disease and thus delayed diagnosis exists with all non-excisional therapies for uterine leiomyomas. The pretreatment imaging before MRgFUS in this case led to an expedited diagnosis of malignancy. Although this did not lead to a change in prognosis for this patient, careful review of magnetic resonance imaging before MRgFUS may allow early diagnosis for uterine malignancies.
| Original language | English (US) |
|---|---|
| Journal | Fertility and Sterility |
| Volume | 90 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 2008 |
| Externally published | Yes |
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Keywords
- diagnosis
- focused ultrasound
- image-guided surgery
- Leiomyoma
- leiomyosarcoma
- magnetic resonance imaging
ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
Avoiding treatment of leiomyosarcomas : the role of magnetic resonance in focused ultrasound surgery. / Samuel, Amber; Fennessy, Fiona M.; Tempany, Clare M C; Stewart, Elizabeth A.
In: Fertility and Sterility, Vol. 90, No. 3, 09.2008.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Avoiding treatment of leiomyosarcomas
T2 - the role of magnetic resonance in focused ultrasound surgery
AU - Samuel, Amber
AU - Fennessy, Fiona M.
AU - Tempany, Clare M C
AU - Stewart, Elizabeth A
PY - 2008/9
Y1 - 2008/9
N2 - Objective: To report early diagnosis of a uterine leiomyosarcoma during screening for magnetic resonance imaging-guided focused ultrasound surgery (MRgFUS) for leiomyomas. Design: Case report. Setting: University hospital conducting an institutional review board-approved clinical trial. Patient(s): A 47-year-old premenopausal woman with presumed symptomatic leiomyomas for 5 years and minimal interval growth. Intervention(s): Magnetic resonance imaging screening protocol used as a routine part of MRgFUS treatment protocol. Main Outcome Measure(s): Surgical pathology report. Result(s): The diagnosis of leiomyosarcoma was suspected at the time of screening, and inadvertent treatment of a leiomyosarcoma was avoided. The patient underwent hysterectomy performed by her referring physician and confirmed the diagnosis of leiomyosarcoma. Conclusion(s): The possibility of inadvertent treatment of malignant disease and thus delayed diagnosis exists with all non-excisional therapies for uterine leiomyomas. The pretreatment imaging before MRgFUS in this case led to an expedited diagnosis of malignancy. Although this did not lead to a change in prognosis for this patient, careful review of magnetic resonance imaging before MRgFUS may allow early diagnosis for uterine malignancies.
AB - Objective: To report early diagnosis of a uterine leiomyosarcoma during screening for magnetic resonance imaging-guided focused ultrasound surgery (MRgFUS) for leiomyomas. Design: Case report. Setting: University hospital conducting an institutional review board-approved clinical trial. Patient(s): A 47-year-old premenopausal woman with presumed symptomatic leiomyomas for 5 years and minimal interval growth. Intervention(s): Magnetic resonance imaging screening protocol used as a routine part of MRgFUS treatment protocol. Main Outcome Measure(s): Surgical pathology report. Result(s): The diagnosis of leiomyosarcoma was suspected at the time of screening, and inadvertent treatment of a leiomyosarcoma was avoided. The patient underwent hysterectomy performed by her referring physician and confirmed the diagnosis of leiomyosarcoma. Conclusion(s): The possibility of inadvertent treatment of malignant disease and thus delayed diagnosis exists with all non-excisional therapies for uterine leiomyomas. The pretreatment imaging before MRgFUS in this case led to an expedited diagnosis of malignancy. Although this did not lead to a change in prognosis for this patient, careful review of magnetic resonance imaging before MRgFUS may allow early diagnosis for uterine malignancies.
KW - diagnosis
KW - focused ultrasound
KW - image-guided surgery
KW - Leiomyoma
KW - leiomyosarcoma
KW - magnetic resonance imaging
UR - http://www.scopus.com/inward/record.url?scp=51549098365&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=51549098365&partnerID=8YFLogxK
U2 - 10.1016/j.fertnstert.2007.08.019
DO - 10.1016/j.fertnstert.2007.08.019
M3 - Article
C2 - 18022163
AN - SCOPUS:51549098365
VL - 90
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 3
ER -