Avoiding treatment of leiomyosarcomas: the role of magnetic resonance in focused ultrasound surgery

Amber Samuel, Fiona M. Fennessy, Clare M C Tempany, Elizabeth A Stewart

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: To report early diagnosis of a uterine leiomyosarcoma during screening for magnetic resonance imaging-guided focused ultrasound surgery (MRgFUS) for leiomyomas. Design: Case report. Setting: University hospital conducting an institutional review board-approved clinical trial. Patient(s): A 47-year-old premenopausal woman with presumed symptomatic leiomyomas for 5 years and minimal interval growth. Intervention(s): Magnetic resonance imaging screening protocol used as a routine part of MRgFUS treatment protocol. Main Outcome Measure(s): Surgical pathology report. Result(s): The diagnosis of leiomyosarcoma was suspected at the time of screening, and inadvertent treatment of a leiomyosarcoma was avoided. The patient underwent hysterectomy performed by her referring physician and confirmed the diagnosis of leiomyosarcoma. Conclusion(s): The possibility of inadvertent treatment of malignant disease and thus delayed diagnosis exists with all non-excisional therapies for uterine leiomyomas. The pretreatment imaging before MRgFUS in this case led to an expedited diagnosis of malignancy. Although this did not lead to a change in prognosis for this patient, careful review of magnetic resonance imaging before MRgFUS may allow early diagnosis for uterine malignancies.

Original languageEnglish (US)
JournalFertility and Sterility
Volume90
Issue number3
DOIs
StatePublished - Sep 2008
Externally publishedYes

Fingerprint

Leiomyosarcoma
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Leiomyoma
Early Diagnosis
Therapeutics
Surgical Pathology
Research Ethics Committees
Delayed Diagnosis
Clinical Protocols
Hysterectomy
Neoplasms
Outcome Assessment (Health Care)
Clinical Trials
Physicians
Growth

Keywords

  • diagnosis
  • focused ultrasound
  • image-guided surgery
  • Leiomyoma
  • leiomyosarcoma
  • magnetic resonance imaging

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Avoiding treatment of leiomyosarcomas : the role of magnetic resonance in focused ultrasound surgery. / Samuel, Amber; Fennessy, Fiona M.; Tempany, Clare M C; Stewart, Elizabeth A.

In: Fertility and Sterility, Vol. 90, No. 3, 09.2008.

Research output: Contribution to journalArticle

@article{af76ee88ddac42f1b3549bdcb625326d,
title = "Avoiding treatment of leiomyosarcomas: the role of magnetic resonance in focused ultrasound surgery",
abstract = "Objective: To report early diagnosis of a uterine leiomyosarcoma during screening for magnetic resonance imaging-guided focused ultrasound surgery (MRgFUS) for leiomyomas. Design: Case report. Setting: University hospital conducting an institutional review board-approved clinical trial. Patient(s): A 47-year-old premenopausal woman with presumed symptomatic leiomyomas for 5 years and minimal interval growth. Intervention(s): Magnetic resonance imaging screening protocol used as a routine part of MRgFUS treatment protocol. Main Outcome Measure(s): Surgical pathology report. Result(s): The diagnosis of leiomyosarcoma was suspected at the time of screening, and inadvertent treatment of a leiomyosarcoma was avoided. The patient underwent hysterectomy performed by her referring physician and confirmed the diagnosis of leiomyosarcoma. Conclusion(s): The possibility of inadvertent treatment of malignant disease and thus delayed diagnosis exists with all non-excisional therapies for uterine leiomyomas. The pretreatment imaging before MRgFUS in this case led to an expedited diagnosis of malignancy. Although this did not lead to a change in prognosis for this patient, careful review of magnetic resonance imaging before MRgFUS may allow early diagnosis for uterine malignancies.",
keywords = "diagnosis, focused ultrasound, image-guided surgery, Leiomyoma, leiomyosarcoma, magnetic resonance imaging",
author = "Amber Samuel and Fennessy, {Fiona M.} and Tempany, {Clare M C} and Stewart, {Elizabeth A}",
year = "2008",
month = "9",
doi = "10.1016/j.fertnstert.2007.08.019",
language = "English (US)",
volume = "90",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Avoiding treatment of leiomyosarcomas

T2 - the role of magnetic resonance in focused ultrasound surgery

AU - Samuel, Amber

AU - Fennessy, Fiona M.

AU - Tempany, Clare M C

AU - Stewart, Elizabeth A

PY - 2008/9

Y1 - 2008/9

N2 - Objective: To report early diagnosis of a uterine leiomyosarcoma during screening for magnetic resonance imaging-guided focused ultrasound surgery (MRgFUS) for leiomyomas. Design: Case report. Setting: University hospital conducting an institutional review board-approved clinical trial. Patient(s): A 47-year-old premenopausal woman with presumed symptomatic leiomyomas for 5 years and minimal interval growth. Intervention(s): Magnetic resonance imaging screening protocol used as a routine part of MRgFUS treatment protocol. Main Outcome Measure(s): Surgical pathology report. Result(s): The diagnosis of leiomyosarcoma was suspected at the time of screening, and inadvertent treatment of a leiomyosarcoma was avoided. The patient underwent hysterectomy performed by her referring physician and confirmed the diagnosis of leiomyosarcoma. Conclusion(s): The possibility of inadvertent treatment of malignant disease and thus delayed diagnosis exists with all non-excisional therapies for uterine leiomyomas. The pretreatment imaging before MRgFUS in this case led to an expedited diagnosis of malignancy. Although this did not lead to a change in prognosis for this patient, careful review of magnetic resonance imaging before MRgFUS may allow early diagnosis for uterine malignancies.

AB - Objective: To report early diagnosis of a uterine leiomyosarcoma during screening for magnetic resonance imaging-guided focused ultrasound surgery (MRgFUS) for leiomyomas. Design: Case report. Setting: University hospital conducting an institutional review board-approved clinical trial. Patient(s): A 47-year-old premenopausal woman with presumed symptomatic leiomyomas for 5 years and minimal interval growth. Intervention(s): Magnetic resonance imaging screening protocol used as a routine part of MRgFUS treatment protocol. Main Outcome Measure(s): Surgical pathology report. Result(s): The diagnosis of leiomyosarcoma was suspected at the time of screening, and inadvertent treatment of a leiomyosarcoma was avoided. The patient underwent hysterectomy performed by her referring physician and confirmed the diagnosis of leiomyosarcoma. Conclusion(s): The possibility of inadvertent treatment of malignant disease and thus delayed diagnosis exists with all non-excisional therapies for uterine leiomyomas. The pretreatment imaging before MRgFUS in this case led to an expedited diagnosis of malignancy. Although this did not lead to a change in prognosis for this patient, careful review of magnetic resonance imaging before MRgFUS may allow early diagnosis for uterine malignancies.

KW - diagnosis

KW - focused ultrasound

KW - image-guided surgery

KW - Leiomyoma

KW - leiomyosarcoma

KW - magnetic resonance imaging

UR - http://www.scopus.com/inward/record.url?scp=51549098365&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=51549098365&partnerID=8YFLogxK

U2 - 10.1016/j.fertnstert.2007.08.019

DO - 10.1016/j.fertnstert.2007.08.019

M3 - Article

C2 - 18022163

AN - SCOPUS:51549098365

VL - 90

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 3

ER -