Avoiding the vicious cycle of prolonged opioid use in Crohn's disease

Jennifer L. Jones, Edward Vincent Loftus, Jr

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

The decision to use opioid analgesics in the management of chronic pain in patients with Crohn's disease is a complex one. Little is known about the effects of long-term high-dose opioids on cognitive function or risk of opioid addiction. At higher doses, opioids affect the gastrointestinal tract adversely and may result in perturbations of the endocrine and immune systems. Distinguishing functional gastrointestinal symptoms from inflammatory symptoms can further complicate this issue. Cross and colleagues have attempted in a retrospective cross-sectional study to identify factors which may predict narcotic use in patients with Crohn's disease. Increased disease activity, polypharmacy (particularly with neuropsychiatric drugs) and cigarette smoking were found to be independent predictors of chronic narcotic use in these patients. Future research in this area is greatly needed to improve patient care. In patients with Crohn's disease, caution should be exercised when it comes to the liberal use of narcotics.

Original languageEnglish (US)
Pages (from-to)2230-2232
Number of pages3
JournalAmerican Journal of Gastroenterology
Volume100
Issue number10
DOIs
StatePublished - Oct 2005

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Crohn Disease
Opioid Analgesics
Narcotics
Polypharmacy
Endocrine System
Chronic Pain
Cognition
Gastrointestinal Tract
Immune System
Patient Care
Cross-Sectional Studies
Smoking
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Avoiding the vicious cycle of prolonged opioid use in Crohn's disease. / Jones, Jennifer L.; Loftus, Jr, Edward Vincent.

In: American Journal of Gastroenterology, Vol. 100, No. 10, 10.2005, p. 2230-2232.

Research output: Contribution to journalReview article

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