AVIATOR: An open international registry to evaluate medical and surgical outcomes of aortic valve insufficiency and ascending aorta aneurysm

Aortic Valve Repair Research Network Investigators

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives: Current national registries are lacking detailed pathology-driven analysis and long-term patients outcomes. The Heart Valve Society (HVS) aortic valve (AV) repair research network started the Aortic Valve Insufficiency and ascending aorta Aneurysm InternATiOnal Registry (AVIATOR) to evaluate long-term patient outcomes of AV repair and replacement. The purpose of the current report is to describe the AVIATOR initiative and report in a descriptive manner the patients included. Methods: The AV repair research network includes surgeons, cardiologists, and scientists and established an online database compliant with the guidelines for reporting valve-related events. Prospective inclusion started from January 2013. Adult patients (18 years or older) who were operated on between 1995 and 2017 with complete procedural specification of the type of repair/replacement were selected for descriptive analysis. Results: Currently 58 centers from 17 countries include 4896 patients with 89% AV repair (n = 4379) versus 11% AV replacement (n = 517). AV repair was either isolated (28%), or associated with tubular/partial root replacement (22%) or valve-sparing root replacement (49%) with an in-hospital mortality of 0.5%, 1.7%, and 1.2%, respectively. AV replacement was either isolated (24%), associated with tubular/partial root replacement (17%) or root replacement (59%) with an in-hospital mortality of 1%, 2.6%, and 2.0%, respectively. Conclusions: The multicenter surgical AVIATOR registry, by applying uniform definitions, should provide a solid evidence base to evaluate the place of repair versus replacement on the basis of long-term patient outcomes. Obtaining data completeness and adequate representation of all surgery types remain challenging. Toward the near future AVIATOR-medical will start to study natural history, as will AVIATOR-kids, with a focus on pediatric disease.

Original languageEnglish (US)
JournalJournal of Thoracic and Cardiovascular Surgery
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Aortic Valve Insufficiency
Aortic Valve
Aneurysm
Registries
Aorta
Hospital Mortality
Heart Valves
Natural History
Research
Surgical Instruments
Databases
Guidelines
Pediatrics
Pathology

Keywords

  • aortic valve regurgitation
  • ascending aortic aneurysm
  • international registry
  • long-term echocardiographic follow-up
  • outcome analysis
  • valve surgery

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

@article{8c9b5909fd1140fe91ed3fd079ede994,
title = "AVIATOR: An open international registry to evaluate medical and surgical outcomes of aortic valve insufficiency and ascending aorta aneurysm",
abstract = "Objectives: Current national registries are lacking detailed pathology-driven analysis and long-term patients outcomes. The Heart Valve Society (HVS) aortic valve (AV) repair research network started the Aortic Valve Insufficiency and ascending aorta Aneurysm InternATiOnal Registry (AVIATOR) to evaluate long-term patient outcomes of AV repair and replacement. The purpose of the current report is to describe the AVIATOR initiative and report in a descriptive manner the patients included. Methods: The AV repair research network includes surgeons, cardiologists, and scientists and established an online database compliant with the guidelines for reporting valve-related events. Prospective inclusion started from January 2013. Adult patients (18 years or older) who were operated on between 1995 and 2017 with complete procedural specification of the type of repair/replacement were selected for descriptive analysis. Results: Currently 58 centers from 17 countries include 4896 patients with 89{\%} AV repair (n = 4379) versus 11{\%} AV replacement (n = 517). AV repair was either isolated (28{\%}), or associated with tubular/partial root replacement (22{\%}) or valve-sparing root replacement (49{\%}) with an in-hospital mortality of 0.5{\%}, 1.7{\%}, and 1.2{\%}, respectively. AV replacement was either isolated (24{\%}), associated with tubular/partial root replacement (17{\%}) or root replacement (59{\%}) with an in-hospital mortality of 1{\%}, 2.6{\%}, and 2.0{\%}, respectively. Conclusions: The multicenter surgical AVIATOR registry, by applying uniform definitions, should provide a solid evidence base to evaluate the place of repair versus replacement on the basis of long-term patient outcomes. Obtaining data completeness and adequate representation of all surgery types remain challenging. Toward the near future AVIATOR-medical will start to study natural history, as will AVIATOR-kids, with a focus on pediatric disease.",
keywords = "aortic valve regurgitation, ascending aortic aneurysm, international registry, long-term echocardiographic follow-up, outcome analysis, valve surgery",
author = "{Aortic Valve Repair Research Network Investigators} and {de Heer}, Frederiek and Jolanda Kluin and Gebrine Elkhoury and Guillaume Jondeau and Sarano, {Maurice E} and Sch{\"a}fers, {Hans Joachim} and Takkenberg, {Johanna J.M.} and Emmanuel Lansac and Christian Dinges and Johannes Steindl and Rosina Ziller and {De Kerchove}, Laurent and Taoufik Benkacem and Corinne Coulon and Fadoua Kaddouri and Vanoverschelde, {Jean Louis} and {de Meester}, Christophe and Agn{\`e}s Pasquet and Jan Nijs and {Van Mosselvelde}, Veerle and Bart Loeys and Bart Meuris and Evi Schepmans and {Van den Bossche}, Klaartje and Peter Verbrugghe and Wenke Goossens and Herbert Gutermann and Matteo Pettinari and Ismail El-Hamamsy and Marien Lenoir and Noly, {Pierre Emmanuel} and Michael Tousch and Pallav Shah and Munir Boodhwani and Igor Rudez and Davor Baric and Daniel Unic and Josip Varvodic and Savica Gjorgijevska and Jan Vojacek and Pavel Zacek and Mikita Karalko and Jaroslav Hlubocky and Robert Novotny and Andrey Slautin and Said Soliman and Eric Arnaud-Crozat and Aude Boignard and Georges Fayad and Olivier Bouchot",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.jtcvs.2018.10.076",
language = "English (US)",
journal = "Journal of Thoracic and Cardiovascular Surgery",
issn = "0022-5223",
publisher = "Mosby Inc.",

}

TY - JOUR

T1 - AVIATOR

T2 - An open international registry to evaluate medical and surgical outcomes of aortic valve insufficiency and ascending aorta aneurysm

AU - Aortic Valve Repair Research Network Investigators

AU - de Heer, Frederiek

AU - Kluin, Jolanda

AU - Elkhoury, Gebrine

AU - Jondeau, Guillaume

AU - Sarano, Maurice E

AU - Schäfers, Hans Joachim

AU - Takkenberg, Johanna J.M.

AU - Lansac, Emmanuel

AU - Dinges, Christian

AU - Steindl, Johannes

AU - Ziller, Rosina

AU - De Kerchove, Laurent

AU - Benkacem, Taoufik

AU - Coulon, Corinne

AU - Kaddouri, Fadoua

AU - Vanoverschelde, Jean Louis

AU - de Meester, Christophe

AU - Pasquet, Agnès

AU - Nijs, Jan

AU - Van Mosselvelde, Veerle

AU - Loeys, Bart

AU - Meuris, Bart

AU - Schepmans, Evi

AU - Van den Bossche, Klaartje

AU - Verbrugghe, Peter

AU - Goossens, Wenke

AU - Gutermann, Herbert

AU - Pettinari, Matteo

AU - El-Hamamsy, Ismail

AU - Lenoir, Marien

AU - Noly, Pierre Emmanuel

AU - Tousch, Michael

AU - Shah, Pallav

AU - Boodhwani, Munir

AU - Rudez, Igor

AU - Baric, Davor

AU - Unic, Daniel

AU - Varvodic, Josip

AU - Gjorgijevska, Savica

AU - Vojacek, Jan

AU - Zacek, Pavel

AU - Karalko, Mikita

AU - Hlubocky, Jaroslav

AU - Novotny, Robert

AU - Slautin, Andrey

AU - Soliman, Said

AU - Arnaud-Crozat, Eric

AU - Boignard, Aude

AU - Fayad, Georges

AU - Bouchot, Olivier

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objectives: Current national registries are lacking detailed pathology-driven analysis and long-term patients outcomes. The Heart Valve Society (HVS) aortic valve (AV) repair research network started the Aortic Valve Insufficiency and ascending aorta Aneurysm InternATiOnal Registry (AVIATOR) to evaluate long-term patient outcomes of AV repair and replacement. The purpose of the current report is to describe the AVIATOR initiative and report in a descriptive manner the patients included. Methods: The AV repair research network includes surgeons, cardiologists, and scientists and established an online database compliant with the guidelines for reporting valve-related events. Prospective inclusion started from January 2013. Adult patients (18 years or older) who were operated on between 1995 and 2017 with complete procedural specification of the type of repair/replacement were selected for descriptive analysis. Results: Currently 58 centers from 17 countries include 4896 patients with 89% AV repair (n = 4379) versus 11% AV replacement (n = 517). AV repair was either isolated (28%), or associated with tubular/partial root replacement (22%) or valve-sparing root replacement (49%) with an in-hospital mortality of 0.5%, 1.7%, and 1.2%, respectively. AV replacement was either isolated (24%), associated with tubular/partial root replacement (17%) or root replacement (59%) with an in-hospital mortality of 1%, 2.6%, and 2.0%, respectively. Conclusions: The multicenter surgical AVIATOR registry, by applying uniform definitions, should provide a solid evidence base to evaluate the place of repair versus replacement on the basis of long-term patient outcomes. Obtaining data completeness and adequate representation of all surgery types remain challenging. Toward the near future AVIATOR-medical will start to study natural history, as will AVIATOR-kids, with a focus on pediatric disease.

AB - Objectives: Current national registries are lacking detailed pathology-driven analysis and long-term patients outcomes. The Heart Valve Society (HVS) aortic valve (AV) repair research network started the Aortic Valve Insufficiency and ascending aorta Aneurysm InternATiOnal Registry (AVIATOR) to evaluate long-term patient outcomes of AV repair and replacement. The purpose of the current report is to describe the AVIATOR initiative and report in a descriptive manner the patients included. Methods: The AV repair research network includes surgeons, cardiologists, and scientists and established an online database compliant with the guidelines for reporting valve-related events. Prospective inclusion started from January 2013. Adult patients (18 years or older) who were operated on between 1995 and 2017 with complete procedural specification of the type of repair/replacement were selected for descriptive analysis. Results: Currently 58 centers from 17 countries include 4896 patients with 89% AV repair (n = 4379) versus 11% AV replacement (n = 517). AV repair was either isolated (28%), or associated with tubular/partial root replacement (22%) or valve-sparing root replacement (49%) with an in-hospital mortality of 0.5%, 1.7%, and 1.2%, respectively. AV replacement was either isolated (24%), associated with tubular/partial root replacement (17%) or root replacement (59%) with an in-hospital mortality of 1%, 2.6%, and 2.0%, respectively. Conclusions: The multicenter surgical AVIATOR registry, by applying uniform definitions, should provide a solid evidence base to evaluate the place of repair versus replacement on the basis of long-term patient outcomes. Obtaining data completeness and adequate representation of all surgery types remain challenging. Toward the near future AVIATOR-medical will start to study natural history, as will AVIATOR-kids, with a focus on pediatric disease.

KW - aortic valve regurgitation

KW - ascending aortic aneurysm

KW - international registry

KW - long-term echocardiographic follow-up

KW - outcome analysis

KW - valve surgery

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U2 - 10.1016/j.jtcvs.2018.10.076

DO - 10.1016/j.jtcvs.2018.10.076

M3 - Article

C2 - 30553597

AN - SCOPUS:85058193656

JO - Journal of Thoracic and Cardiovascular Surgery

JF - Journal of Thoracic and Cardiovascular Surgery

SN - 0022-5223

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