Autosome search for schizophrenia susceptibility genes in multiply affected families

M. I. Rees; I. Fenton; N. M. Williams; P. Holmans; N. Norton; A. Cardno; P. Asherson; G. Spurlock; E. Roberts; E. Parfitt; R. Mant; H. Vallada; E. Dawson; M. W. Li; D. A. Collier; J. F. Powell; S. Nanko; M. Gill; P. McGuffin; M. J. Owen

doi:10.1038/sj.mp.4000521

Autosome search for schizophrenia susceptibility genes in multiply affected families

M. I. Rees, I. Fenton, N. M. Williams, P. Holmans, N. Norton, A. Cardno, P. Asherson, G. Spurlock, E. Roberts, E. Parfitt, R. Mant, H. Vallada, E. Dawson, M. W. Li, D. A. Collier, J. F. Powell, S. Nanko, M. Gill, P. McGuffin, M. J. Owen

Cancer Biology

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Abstract

We have analysed 298 polymorphic markers in 13 families multiply affected with schizophrenia and related disorders using a combination of radiolabelled and fluorescent-based methodologies. The markers were distributed throughout the autosomes at an average spacing of 12.8 cM. The data were analysed with two-point linkage analysis (MLINK) and heterogeneity testing (HOMOG). Several genetic models were used ranging from near dominant to fully recessive. Multi-point analysis was performed for 27 regions demonstrating either contiguously positive lod scores in two or more consecutive markers, and in regions with two-point lod score(s) of 1.0 or above in a single marker. A proportion of the multi-point regions have been implicated in previous studies, thereby decreasing risk of false-positive results. However neither our two-point, nor multi-point scores reached the threshold value for significance of 3.6. Nevertheless three regions were suggestive of linkage.

Original language	English (US)
Pages (from-to)	353-359
Number of pages	7
Journal	Molecular Psychiatry
Volume	4
Issue number	4
DOIs	https://doi.org/10.1038/sj.mp.4000521
State	Published - 1999

Keywords

Genome scan
Linkage analysis
Schizophrenia families
Schizophrenia susceptibility regions

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience
Psychiatry and Mental health

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10.1038/sj.mp.4000521

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Rees, M. I., Fenton, I., Williams, N. M., Holmans, P., Norton, N., Cardno, A., Asherson, P., Spurlock, G., Roberts, E., Parfitt, E., Mant, R., Vallada, H., Dawson, E., Li, M. W., Collier, D. A., Powell, J. F., Nanko, S., Gill, M., McGuffin, P., & Owen, M. J. (1999). Autosome search for schizophrenia susceptibility genes in multiply affected families. Molecular Psychiatry, 4(4), 353-359. https://doi.org/10.1038/sj.mp.4000521

Rees, MI, Fenton, I, Williams, NM, Holmans, P, Norton, N, Cardno, A, Asherson, P, Spurlock, G, Roberts, E, Parfitt, E, Mant, R, Vallada, H, Dawson, E, Li, MW, Collier, DA, Powell, JF, Nanko, S, Gill, M, McGuffin, P & Owen, MJ 1999, 'Autosome search for schizophrenia susceptibility genes in multiply affected families', Molecular Psychiatry, vol. 4, no. 4, pp. 353-359. https://doi.org/10.1038/sj.mp.4000521

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title = "Autosome search for schizophrenia susceptibility genes in multiply affected families",

abstract = "We have analysed 298 polymorphic markers in 13 families multiply affected with schizophrenia and related disorders using a combination of radiolabelled and fluorescent-based methodologies. The markers were distributed throughout the autosomes at an average spacing of 12.8 cM. The data were analysed with two-point linkage analysis (MLINK) and heterogeneity testing (HOMOG). Several genetic models were used ranging from near dominant to fully recessive. Multi-point analysis was performed for 27 regions demonstrating either contiguously positive lod scores in two or more consecutive markers, and in regions with two-point lod score(s) of 1.0 or above in a single marker. A proportion of the multi-point regions have been implicated in previous studies, thereby decreasing risk of false-positive results. However neither our two-point, nor multi-point scores reached the threshold value for significance of 3.6. Nevertheless three regions were suggestive of linkage.",

keywords = "Genome scan, Linkage analysis, Schizophrenia families, Schizophrenia susceptibility regions",

author = "Rees, {M. I.} and I. Fenton and Williams, {N. M.} and P. Holmans and N. Norton and A. Cardno and P. Asherson and G. Spurlock and E. Roberts and E. Parfitt and R. Mant and H. Vallada and E. Dawson and Li, {M. W.} and Collier, {D. A.} and Powell, {J. F.} and S. Nanko and M. Gill and P. McGuffin and Owen, {M. J.}",

note = "Funding Information: This work was supported by grants from the MRC (Nos G9209834 and G9309810) and the Welsh Scheme for the Development of Health and Social Research. MG was supported by the Wellcome Trust during this collaboration.",

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doi = "10.1038/sj.mp.4000521",

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pages = "353--359",

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AU - Rees, M. I.

AU - Fenton, I.

AU - Williams, N. M.

AU - Holmans, P.

AU - Norton, N.

AU - Cardno, A.

AU - Asherson, P.

AU - Spurlock, G.

AU - Roberts, E.

AU - Parfitt, E.

AU - Mant, R.

AU - Vallada, H.

AU - Dawson, E.

AU - Li, M. W.

AU - Collier, D. A.

AU - Powell, J. F.

AU - Nanko, S.

AU - Gill, M.

AU - McGuffin, P.

AU - Owen, M. J.

N1 - Funding Information: This work was supported by grants from the MRC (Nos G9209834 and G9309810) and the Welsh Scheme for the Development of Health and Social Research. MG was supported by the Wellcome Trust during this collaboration.

PY - 1999

Y1 - 1999

N2 - We have analysed 298 polymorphic markers in 13 families multiply affected with schizophrenia and related disorders using a combination of radiolabelled and fluorescent-based methodologies. The markers were distributed throughout the autosomes at an average spacing of 12.8 cM. The data were analysed with two-point linkage analysis (MLINK) and heterogeneity testing (HOMOG). Several genetic models were used ranging from near dominant to fully recessive. Multi-point analysis was performed for 27 regions demonstrating either contiguously positive lod scores in two or more consecutive markers, and in regions with two-point lod score(s) of 1.0 or above in a single marker. A proportion of the multi-point regions have been implicated in previous studies, thereby decreasing risk of false-positive results. However neither our two-point, nor multi-point scores reached the threshold value for significance of 3.6. Nevertheless three regions were suggestive of linkage.

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KW - Schizophrenia families

KW - Schizophrenia susceptibility regions

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Autosome search for schizophrenia susceptibility genes in multiply affected families

Abstract

Keywords

ASJC Scopus subject areas

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