Autosome search for schizophrenia susceptibility genes in multiply affected families

M. I. Rees, I. Fenton, N. M. Williams, P. Holmans, N. Norton, A. Cardno, P. Asherson, G. Spurlock, E. Roberts, E. Parfitt, R. Mant, H. Vallada, E. Dawson, M. W. Li, D. A. Collier, J. F. Powell, S. Nanko, M. Gill, P. McGuffin, M. J. Owen

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

We have analysed 298 polymorphic markers in 13 families multiply affected with schizophrenia and related disorders using a combination of radiolabelled and fluorescent-based methodologies. The markers were distributed throughout the autosomes at an average spacing of 12.8 cM. The data were analysed with two-point linkage analysis (MLINK) and heterogeneity testing (HOMOG). Several genetic models were used ranging from near dominant to fully recessive. Multi-point analysis was performed for 27 regions demonstrating either contiguously positive lod scores in two or more consecutive markers, and in regions with two-point lod score(s) of 1.0 or above in a single marker. A proportion of the multi-point regions have been implicated in previous studies, thereby decreasing risk of false-positive results. However neither our two-point, nor multi-point scores reached the threshold value for significance of 3.6. Nevertheless three regions were suggestive of linkage.

Original languageEnglish (US)
Pages (from-to)353-359
Number of pages7
JournalMolecular Psychiatry
Volume4
Issue number4
DOIs
StatePublished - Jan 1 1999

Keywords

  • Genome scan
  • Linkage analysis
  • Schizophrenia families
  • Schizophrenia susceptibility regions

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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    Rees, M. I., Fenton, I., Williams, N. M., Holmans, P., Norton, N., Cardno, A., Asherson, P., Spurlock, G., Roberts, E., Parfitt, E., Mant, R., Vallada, H., Dawson, E., Li, M. W., Collier, D. A., Powell, J. F., Nanko, S., Gill, M., McGuffin, P., & Owen, M. J. (1999). Autosome search for schizophrenia susceptibility genes in multiply affected families. Molecular Psychiatry, 4(4), 353-359. https://doi.org/10.1038/sj.mp.4000521