Autosomal-dominant polycystic kidney disease (ADPKD): Executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Arlene B. Chapman; Olivier Devuyst; Kai Uwe Eckardt; Ron T. Gansevoort; Tess Harris; Shigeo Horie; Bertram L. Kasiske; Dwight Odland; York Pei; Ronald D. Perrone; Yves Pirson; Robert W. Schrier; Roser Torra; Vicente E. Torres; Terry Watnick; David C. Wheeler; Curie Ahn; Ahsan Alam; Beatrice Aussilhou; Kyongtae T. Bae; William M. Bennett; Carsten Bergmann; Daniel G. Bichet; Klemens Budde; Dominique Chauveau; Benjamin Cowley; Brenda De Coninck; Katherine M. Dell; Joost P.H. Drenth; Tevfik Ecder; Francesco Emma; Claude Férec; Bruno Flamion; Flavia Galletti; Bernice Gitomer; Jared J. Grantham; Nicole Harr; Peter C. Harris; Eiji Higashihara; Eiko Hodouchi; Marie C. Hogan; Vivek Jha; Uwe Korst; Corinne Lagrafeuil; Rodolfo S. Martin; Changlin Mei; Michal Mrug; Gregorio T. Obrador; Albert C.M. Ong; Luiz F. Onuchic; Luisa Sternfeld Pavia; Gopala K. Rangan; Richard Sandford; Andreas L. Serra; Theodore I. Steinman; Svend Strandgaard; Gerd Walz; Christopher G. Winearls; Kaori Yamane Winston

doi:10.1038/ki.2015.59

Autosomal-dominant polycystic kidney disease (ADPKD): Executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Arlene B. Chapman, Olivier Devuyst, Kai Uwe Eckardt, Ron T. Gansevoort, Tess Harris, Shigeo Horie, Bertram L. Kasiske, Dwight Odland, York Pei, Ronald D. Perrone, Yves Pirson, Robert W. Schrier, Roser Torra, Vicente E. Torres, Terry Watnick, David C. Wheeler, Curie Ahn, Ahsan Alam, Beatrice Aussilhou, Kyongtae T. BaeWilliam M. Bennett, Carsten Bergmann, Daniel G. Bichet, Klemens Budde, Dominique Chauveau, Benjamin Cowley, Brenda De Coninck, Katherine M. Dell, Joost P.H. Drenth, Tevfik Ecder, Francesco Emma, Claude Férec, Bruno Flamion, Flavia Galletti, Bernice Gitomer, Jared J. Grantham, Nicole Harr, Peter C. Harris, Eiji Higashihara, Eiko Hodouchi, Marie C. Hogan, Vivek Jha, Uwe Korst, Corinne Lagrafeuil, Rodolfo S. Martin, Changlin Mei, Michal Mrug, Gregorio T. Obrador, Albert C.M. Ong, Luiz F. Onuchic, Luisa Sternfeld Pavia, Gopala K. Rangan, Richard Sandford, Andreas L. Serra, Theodore I. Steinman, Svend Strandgaard, Gerd Walz, Christopher G. Winearls, Kaori Yamane Winston

Nephrology and Hypertension

Research output: Contribution to journal › Article › peer-review

232 Scopus citations

Abstract

Autosomal-dominant polycystic kidney disease (ADPKD) affects up to 12 million individuals and is the fourth most common cause for renal replacement therapy worldwide. There have been many recent advances in the understanding of its molecular genetics and biology, and in the diagnosis and management of its manifestations. Yet, diagnosis, evaluation, prevention, and treatment vary widely and there are no broadly accepted practice guidelines. Barriers to translation of basic science breakthroughs to clinical care exist, with considerable heterogeneity across countries. The Kidney Disease: Improving Global Outcomes Controversies Conference on ADPKD brought together a panel of multidisciplinary clinical expertise and engaged patients to identify areas of consensus, gaps in knowledge, and research and health-care priorities related to diagnosis; monitoring of kidney disease progression; management of hypertension, renal function decline and complications; end-stage renal disease; extrarenal complications; and practical integrated patient support. These are summarized in this review.

Original language	English (US)
Pages (from-to)	17-27
Number of pages	11
Journal	Kidney international
Volume	88
Issue number	1
DOIs	https://doi.org/10.1038/ki.2015.59
State	Published - Jul 2 2015

Keywords

Diagnosis
End-stage renal disease
Management
Patient support
Polycystic kidney disease

ASJC Scopus subject areas

Nephrology

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10.1038/ki.2015.59

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Chapman, A. B., Devuyst, O., Eckardt, K. U., Gansevoort, R. T., Harris, T., Horie, S., Kasiske, B. L., Odland, D., Pei, Y., Perrone, R. D., Pirson, Y., Schrier, R. W., Torra, R., Torres, V. E., Watnick, T., Wheeler, D. C., Ahn, C., Alam, A., Aussilhou, B., ... Winston, K. Y. (2015). Autosomal-dominant polycystic kidney disease (ADPKD): Executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney international, 88(1), 17-27. https://doi.org/10.1038/ki.2015.59

Chapman, AB, Devuyst, O, Eckardt, KU, Gansevoort, RT, Harris, T, Horie, S, Kasiske, BL, Odland, D, Pei, Y, Perrone, RD, Pirson, Y, Schrier, RW, Torra, R, Torres, VE, Watnick, T, Wheeler, DC, Ahn, C, Alam, A, Aussilhou, B, Bae, KT, Bennett, WM, Bergmann, C, Bichet, DG, Budde, K, Chauveau, D, Cowley, B, De Coninck, B, Dell, KM, Drenth, JPH, Ecder, T, Emma, F, Férec, C, Flamion, B, Galletti, F, Gitomer, B, Grantham, JJ, Harr, N, Harris, PC, Higashihara, E, Hodouchi, E, Hogan, MC, Jha, V, Korst, U, Lagrafeuil, C, Martin, RS, Mei, C, Mrug, M, Obrador, GT, Ong, ACM, Onuchic, LF, Pavia, LS, Rangan, GK, Sandford, R, Serra, AL, Steinman, TI, Strandgaard, S, Walz, G, Winearls, CG & Winston, KY 2015, 'Autosomal-dominant polycystic kidney disease (ADPKD): Executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference', Kidney international, vol. 88, no. 1, pp. 17-27. https://doi.org/10.1038/ki.2015.59

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title = "Autosomal-dominant polycystic kidney disease (ADPKD): Executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference",

abstract = "Autosomal-dominant polycystic kidney disease (ADPKD) affects up to 12 million individuals and is the fourth most common cause for renal replacement therapy worldwide. There have been many recent advances in the understanding of its molecular genetics and biology, and in the diagnosis and management of its manifestations. Yet, diagnosis, evaluation, prevention, and treatment vary widely and there are no broadly accepted practice guidelines. Barriers to translation of basic science breakthroughs to clinical care exist, with considerable heterogeneity across countries. The Kidney Disease: Improving Global Outcomes Controversies Conference on ADPKD brought together a panel of multidisciplinary clinical expertise and engaged patients to identify areas of consensus, gaps in knowledge, and research and health-care priorities related to diagnosis; monitoring of kidney disease progression; management of hypertension, renal function decline and complications; end-stage renal disease; extrarenal complications; and practical integrated patient support. These are summarized in this review.",

keywords = "Diagnosis, End-stage renal disease, Management, Patient support, Polycystic kidney disease",

author = "Chapman, {Arlene B.} and Olivier Devuyst and Eckardt, {Kai Uwe} and Gansevoort, {Ron T.} and Tess Harris and Shigeo Horie and Kasiske, {Bertram L.} and Dwight Odland and York Pei and Perrone, {Ronald D.} and Yves Pirson and Schrier, {Robert W.} and Roser Torra and Torres, {Vicente E.} and Terry Watnick and Wheeler, {David C.} and Curie Ahn and Ahsan Alam and Beatrice Aussilhou and Bae, {Kyongtae T.} and Bennett, {William M.} and Carsten Bergmann and Bichet, {Daniel G.} and Klemens Budde and Dominique Chauveau and Benjamin Cowley and {De Coninck}, Brenda and Dell, {Katherine M.} and Drenth, {Joost P.H.} and Tevfik Ecder and Francesco Emma and Claude F{\'e}rec and Bruno Flamion and Flavia Galletti and Bernice Gitomer and Grantham, {Jared J.} and Nicole Harr and Harris, {Peter C.} and Eiji Higashihara and Eiko Hodouchi and Hogan, {Marie C.} and Vivek Jha and Uwe Korst and Corinne Lagrafeuil and Martin, {Rodolfo S.} and Changlin Mei and Michal Mrug and Obrador, {Gregorio T.} and Ong, {Albert C.M.} and Onuchic, {Luiz F.} and Pavia, {Luisa Sternfeld} and Rangan, {Gopala K.} and Richard Sandford and Serra, {Andreas L.} and Steinman, {Theodore I.} and Svend Strandgaard and Gerd Walz and Winearls, {Christopher G.} and Winston, {Kaori Yamane}",

note = "Publisher Copyright: {\textcopyright} 2015 International Society of Nephrology.",

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doi = "10.1038/ki.2015.59",

language = "English (US)",

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T2 - Executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

AU - Chapman, Arlene B.

AU - Devuyst, Olivier

AU - Eckardt, Kai Uwe

AU - Gansevoort, Ron T.

AU - Harris, Tess

AU - Horie, Shigeo

AU - Kasiske, Bertram L.

AU - Odland, Dwight

AU - Pei, York

AU - Perrone, Ronald D.

AU - Pirson, Yves

AU - Schrier, Robert W.

AU - Torra, Roser

AU - Torres, Vicente E.

AU - Watnick, Terry

AU - Wheeler, David C.

AU - Ahn, Curie

AU - Alam, Ahsan

AU - Aussilhou, Beatrice

AU - Bae, Kyongtae T.

AU - Bennett, William M.

AU - Bergmann, Carsten

AU - Bichet, Daniel G.

AU - Budde, Klemens

AU - Chauveau, Dominique

AU - Cowley, Benjamin

AU - De Coninck, Brenda

AU - Dell, Katherine M.

AU - Drenth, Joost P.H.

AU - Ecder, Tevfik

AU - Emma, Francesco

AU - Férec, Claude

AU - Flamion, Bruno

AU - Galletti, Flavia

AU - Gitomer, Bernice

AU - Grantham, Jared J.

AU - Harr, Nicole

AU - Harris, Peter C.

AU - Higashihara, Eiji

AU - Hodouchi, Eiko

AU - Hogan, Marie C.

AU - Jha, Vivek

AU - Korst, Uwe

AU - Lagrafeuil, Corinne

AU - Martin, Rodolfo S.

AU - Mei, Changlin

AU - Mrug, Michal

AU - Obrador, Gregorio T.

AU - Ong, Albert C.M.

AU - Onuchic, Luiz F.

AU - Pavia, Luisa Sternfeld

AU - Rangan, Gopala K.

AU - Sandford, Richard

AU - Serra, Andreas L.

AU - Steinman, Theodore I.

AU - Strandgaard, Svend

AU - Walz, Gerd

AU - Winearls, Christopher G.

AU - Winston, Kaori Yamane

PY - 2015/7/2

Y1 - 2015/7/2

N2 - Autosomal-dominant polycystic kidney disease (ADPKD) affects up to 12 million individuals and is the fourth most common cause for renal replacement therapy worldwide. There have been many recent advances in the understanding of its molecular genetics and biology, and in the diagnosis and management of its manifestations. Yet, diagnosis, evaluation, prevention, and treatment vary widely and there are no broadly accepted practice guidelines. Barriers to translation of basic science breakthroughs to clinical care exist, with considerable heterogeneity across countries. The Kidney Disease: Improving Global Outcomes Controversies Conference on ADPKD brought together a panel of multidisciplinary clinical expertise and engaged patients to identify areas of consensus, gaps in knowledge, and research and health-care priorities related to diagnosis; monitoring of kidney disease progression; management of hypertension, renal function decline and complications; end-stage renal disease; extrarenal complications; and practical integrated patient support. These are summarized in this review.

AB - Autosomal-dominant polycystic kidney disease (ADPKD) affects up to 12 million individuals and is the fourth most common cause for renal replacement therapy worldwide. There have been many recent advances in the understanding of its molecular genetics and biology, and in the diagnosis and management of its manifestations. Yet, diagnosis, evaluation, prevention, and treatment vary widely and there are no broadly accepted practice guidelines. Barriers to translation of basic science breakthroughs to clinical care exist, with considerable heterogeneity across countries. The Kidney Disease: Improving Global Outcomes Controversies Conference on ADPKD brought together a panel of multidisciplinary clinical expertise and engaged patients to identify areas of consensus, gaps in knowledge, and research and health-care priorities related to diagnosis; monitoring of kidney disease progression; management of hypertension, renal function decline and complications; end-stage renal disease; extrarenal complications; and practical integrated patient support. These are summarized in this review.

KW - Diagnosis

KW - End-stage renal disease

KW - Management

KW - Patient support

KW - Polycystic kidney disease

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Autosomal-dominant polycystic kidney disease (ADPKD): Executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Abstract

Keywords

ASJC Scopus subject areas

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