Autosomal dominant polycystic kidney disease

Research output: Contribution to journalReview articlepeer-review

849 Scopus citations

Abstract

Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal, monogenic disorder. It is associated with large interfamilial and intrafamilial variability, which can be explained to a large extent by its genetic heterogeneity and modifier genes. An increased understanding of the disorder's underlying genetic, molecular, and cellular mechanisms and a better appreciation of its progression and systemic manifestations have laid out the foundation for the development of clinical trials and potentially effective treatments.

Original languageEnglish (US)
Pages (from-to)1287-1301
Number of pages15
JournalLancet
Volume369
Issue number9569
DOIs
StatePublished - Apr 14 2007

ASJC Scopus subject areas

  • Medicine(all)

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