Autosomal-dominant Parkinson's disease linked to 2p13 is not caused by mutations in transforming growth factor alpha (TGF alpha)

M. Zink, L. Grimm, Z. K. Wszolek, T. Gasser

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A susceptibility gene for Parkinson's disease (PD) with late onset and typical Lewy-body pathology maps to chromosome 2p13 (PARK3). In the present study we examined the gene for transforming growth factor alpha (TGF alpha), which is located in the PARK3-region, as a potential candidate gene. This polypeptide mitogen exerts trophic actions on dopaminergic neurons and TGF alpha-deficient mice have fewer dopaminergic neurons. We did not find mutations in the exonic or exon-flanking intronic sequences of index patients of two families linked to 2p13. This result excludes mutations in the coding region of TGF alpha as a cause for hereditary PD, but does not rule out a possible role of sequence variants in regulatory regions or splice sites.

Original languageEnglish (US)
Pages (from-to)1029-1034
Number of pages6
JournalJournal of Neurology
Volume248
Issue number9
StatePublished - Sep 12 2001

Keywords

  • Autosomal dominant
  • Exon intron boundaries
  • Neurogenetics
  • Parkinson's disease
  • Transforming growth factor alpha

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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