Autosomal-dominant Parkinson's disease linked to 2p13 is not caused by mutations in transforming growth factor alpha (TGF alpha) (short communication).

M. Zink, L. Grim, Zbigniew K Wszolek, T. Gasser

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2 Citations (Scopus)

Abstract

A susceptibility gene for Parkinson's disease (PD) with late onset and typical Lewy-body pathology maps to chromosome 2p13 (PARK3). In the present study we examined the gene for transforming growth factor alpha (TGF alpha), which is located in the PARK3-region, as a potential candidate gene. This polypeptide mitogen exerts trophic actions on dopaminergic neurons and TGF alpha-deficient mice have fewer dopaminergic neurons. We did not find mutations in the exonic or exon-flanking intronic sequences of index patients of two families linked to 2p13. This result excludes mutations in the coding region of TGF alpha as a cause for hereditary PD, but does not rule out a possible role of sequence variants in regulatory regions or splice sites.

Original languageEnglish (US)
Pages (from-to)1029-1034
Number of pages6
JournalJournal of neural transmission (Vienna, Austria : 1996)
Volume108
Issue number8-9
DOIs
StatePublished - 2001

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Transforming Growth Factor alpha
Dopaminergic Neurons
Communication
Mutation
Parkinson Disease
Genes
Lewy Bodies
Inborn Genetic Diseases
Nucleic Acid Regulatory Sequences
Mitogens
Exons
Chromosomes
Pathology
Peptides
Parkinson Disease, Familial, Type 1

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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abstract = "A susceptibility gene for Parkinson's disease (PD) with late onset and typical Lewy-body pathology maps to chromosome 2p13 (PARK3). In the present study we examined the gene for transforming growth factor alpha (TGF alpha), which is located in the PARK3-region, as a potential candidate gene. This polypeptide mitogen exerts trophic actions on dopaminergic neurons and TGF alpha-deficient mice have fewer dopaminergic neurons. We did not find mutations in the exonic or exon-flanking intronic sequences of index patients of two families linked to 2p13. This result excludes mutations in the coding region of TGF alpha as a cause for hereditary PD, but does not rule out a possible role of sequence variants in regulatory regions or splice sites.",
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AU - Gasser, T.

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