@article{431b2cd2d1e248e68fdfad15a1d4bcb4,
title = "Autophagy in Parkinson's Disease",
abstract = "Impaired protein homeostasis and accumulation of damaged or abnormally modified protein are common disease mechanisms in many neurodegenerative disorders, including Parkinson's disease (PD). As one of the major degradation pathways, autophagy plays a pivotal role in maintaining effective turnover of proteins and damaged organelles in cells. Several decades of research efforts led to insights into the potential contribution of impaired autophagy machinery to α-synuclein accumulation and the degeneration of dopaminergic neurons, two major features of PD pathology. In this review, we summarize recent pathological, genetic, and mechanistic findings that link defective autophagy with PD pathogenesis in human patients, animals, and cellular models and discuss current challenges in the field.",
keywords = "Parkinson's disease, chaperone-mediated autophagy, macroautophagy, mitophagy, α-synuclein",
author = "Xu Hou and Watzlawik, {Jens O.} and Fiesel, {Fabienne C.} and Wolfdieter Springer",
note = "Funding Information: W.S. is partially supported by the National Institute of Neurological Disorders and Stroke (NINDS) , USA [ R01 NS085070 and U54 NS110435 ], the National Institute of Aging (NIA) , USA [ R56 AG062556 ], the Department of Defense Congressionally Directed Medical Research Programs (CDMRP) , USA [ W81XWH-17-1-0248 ], the Florida Department of Health - Ed and Ethel Moore Alzheimer{\textquoteright}s Disease Research Program , USA [ 9AZ10 ], the Michael J. Fox Foundation for Parkinson{\textquoteright}s Research (MJFF) , USA, Mayo Clinic Foundation and the Center for Biomedical Discovery (CBD) , USA. X.H. is supported by a pilot grant from the Mayo Clinic Alzheimer Disease Research Center (ADRC) and a fellowship awarded by the American Parkinson Disease Association (APDA) , USA. F.C.F. is the recipient of fellowships from the Younkin Scholar Program and the APDA and is supported in part by the MJFF and a Gerstner Family Career Development Award from the Mayo Clinic Center for Individualized Medicine (CIM) , USA. Funding Information: W.S. is partially supported by the National Institute of Neurological Disorders and Stroke (NINDS), USA [R01 NS085070 and U54 NS110435], the National Institute of Aging (NIA), USA [R56 AG062556], the Department of Defense Congressionally Directed Medical Research Programs (CDMRP), USA [W81XWH-17-1-0248], the Florida Department of Health - Ed and Ethel Moore Alzheimer's Disease Research Program, USA [9AZ10], the Michael J. Fox Foundation for Parkinson's Research (MJFF), USA, Mayo Clinic Foundation and the Center for Biomedical Discovery (CBD), USA. X.H. is supported by a pilot grant from the Mayo Clinic Alzheimer Disease Research Center (ADRC) and a fellowship awarded by the American Parkinson Disease Association (APDA), USA. F.C.F. is the recipient of fellowships from the Younkin Scholar Program and the APDA and is supported in part by the MJFF and a Gerstner Family Career Development Award from the Mayo Clinic Center for Individualized Medicine (CIM), USA. Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = apr,
day = "3",
doi = "10.1016/j.jmb.2020.01.037",
language = "English (US)",
volume = "432",
pages = "2651--2672",
journal = "Journal of Molecular Biology",
issn = "0022-2836",
publisher = "Academic Press Inc.",
number = "8",
}