Autonomic function, as self-reported on the SCOPA-autonomic questionnaire, is normal in essential tremor but not in Parkinson's disease

Anne Damian, Charles Howard Adler, Joseph G. Hentz, Holly A. Shill, John Nathaniel Caviness, Marwan N. Sabbagh, Virgilio G H Evidente, Thomas G. Beach, Erika M Driver-Dunckley

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Objective: To compare autonomic function of subjects with Parkinson's disease (PD) and essential tremor (ET) relative to controls. Background: It has been reported that patients with PD have autonomic dysfunction while no literature exists regarding autonomic function in ET. Methods: Subjects with PD, ET, and controls had autonomic function measured using the SCOPA-Autonomic questionnaire, with the total and domain scores transformed to a scale of 0-100 points. Results: 62 subjects with PD, 84 with ET, and 291 controls were included. Women were more prevalent in control (69%) compared to PD (44%) and ET (44%) groups, and mean age was significantly younger in PD (73 yrs) and older in ET (83) compared to controls (81). The mean SCOPA-Aut Total score in PD was significantly higher than controls, with no difference in ET. No autonomic dysfunction was found in any domain in ET but in PD there were significant abnormalities in gastrointestinal, cardiovascular, urinary, and thermoregulatory domains. Individual question data revealed a significantly higher percentage of subjects with dysfunction on 11/23 questions in the PD group but only 1 question (sialorrhea) in the ET group compared with controls. Conclusion: Autonomic scores, particularly gastrointestinal, cardiovascular, urinary, and thermoregulatory were increased in patients with PD, as assessed by SCOPA-Aut. Patients with ET did not exhibit autonomic dysfunction, with the exception of sialorrhea.

Original languageEnglish (US)
Pages (from-to)1089-1093
Number of pages5
JournalParkinsonism and Related Disorders
Volume18
Issue number10
DOIs
StatePublished - Dec 2012

Fingerprint

Essential Tremor
Parkinson Disease
Sialorrhea
Surveys and Questionnaires
Age Groups

Keywords

  • Autonomic dysfunction
  • Essential tremor
  • Parkinson's disease

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neurology

Cite this

Autonomic function, as self-reported on the SCOPA-autonomic questionnaire, is normal in essential tremor but not in Parkinson's disease. / Damian, Anne; Adler, Charles Howard; Hentz, Joseph G.; Shill, Holly A.; Caviness, John Nathaniel; Sabbagh, Marwan N.; Evidente, Virgilio G H; Beach, Thomas G.; Driver-Dunckley, Erika M.

In: Parkinsonism and Related Disorders, Vol. 18, No. 10, 12.2012, p. 1089-1093.

Research output: Contribution to journalArticle

@article{1d2bb7b8aacd49079d23e47d4846b862,
title = "Autonomic function, as self-reported on the SCOPA-autonomic questionnaire, is normal in essential tremor but not in Parkinson's disease",
abstract = "Objective: To compare autonomic function of subjects with Parkinson's disease (PD) and essential tremor (ET) relative to controls. Background: It has been reported that patients with PD have autonomic dysfunction while no literature exists regarding autonomic function in ET. Methods: Subjects with PD, ET, and controls had autonomic function measured using the SCOPA-Autonomic questionnaire, with the total and domain scores transformed to a scale of 0-100 points. Results: 62 subjects with PD, 84 with ET, and 291 controls were included. Women were more prevalent in control (69{\%}) compared to PD (44{\%}) and ET (44{\%}) groups, and mean age was significantly younger in PD (73 yrs) and older in ET (83) compared to controls (81). The mean SCOPA-Aut Total score in PD was significantly higher than controls, with no difference in ET. No autonomic dysfunction was found in any domain in ET but in PD there were significant abnormalities in gastrointestinal, cardiovascular, urinary, and thermoregulatory domains. Individual question data revealed a significantly higher percentage of subjects with dysfunction on 11/23 questions in the PD group but only 1 question (sialorrhea) in the ET group compared with controls. Conclusion: Autonomic scores, particularly gastrointestinal, cardiovascular, urinary, and thermoregulatory were increased in patients with PD, as assessed by SCOPA-Aut. Patients with ET did not exhibit autonomic dysfunction, with the exception of sialorrhea.",
keywords = "Autonomic dysfunction, Essential tremor, Parkinson's disease",
author = "Anne Damian and Adler, {Charles Howard} and Hentz, {Joseph G.} and Shill, {Holly A.} and Caviness, {John Nathaniel} and Sabbagh, {Marwan N.} and Evidente, {Virgilio G H} and Beach, {Thomas G.} and Driver-Dunckley, {Erika M}",
year = "2012",
month = "12",
doi = "10.1016/j.parkreldis.2012.06.008",
language = "English (US)",
volume = "18",
pages = "1089--1093",
journal = "Parkinsonism and Related Disorders",
issn = "1353-8020",
publisher = "Elsevier BV",
number = "10",

}

TY - JOUR

T1 - Autonomic function, as self-reported on the SCOPA-autonomic questionnaire, is normal in essential tremor but not in Parkinson's disease

AU - Damian, Anne

AU - Adler, Charles Howard

AU - Hentz, Joseph G.

AU - Shill, Holly A.

AU - Caviness, John Nathaniel

AU - Sabbagh, Marwan N.

AU - Evidente, Virgilio G H

AU - Beach, Thomas G.

AU - Driver-Dunckley, Erika M

PY - 2012/12

Y1 - 2012/12

N2 - Objective: To compare autonomic function of subjects with Parkinson's disease (PD) and essential tremor (ET) relative to controls. Background: It has been reported that patients with PD have autonomic dysfunction while no literature exists regarding autonomic function in ET. Methods: Subjects with PD, ET, and controls had autonomic function measured using the SCOPA-Autonomic questionnaire, with the total and domain scores transformed to a scale of 0-100 points. Results: 62 subjects with PD, 84 with ET, and 291 controls were included. Women were more prevalent in control (69%) compared to PD (44%) and ET (44%) groups, and mean age was significantly younger in PD (73 yrs) and older in ET (83) compared to controls (81). The mean SCOPA-Aut Total score in PD was significantly higher than controls, with no difference in ET. No autonomic dysfunction was found in any domain in ET but in PD there were significant abnormalities in gastrointestinal, cardiovascular, urinary, and thermoregulatory domains. Individual question data revealed a significantly higher percentage of subjects with dysfunction on 11/23 questions in the PD group but only 1 question (sialorrhea) in the ET group compared with controls. Conclusion: Autonomic scores, particularly gastrointestinal, cardiovascular, urinary, and thermoregulatory were increased in patients with PD, as assessed by SCOPA-Aut. Patients with ET did not exhibit autonomic dysfunction, with the exception of sialorrhea.

AB - Objective: To compare autonomic function of subjects with Parkinson's disease (PD) and essential tremor (ET) relative to controls. Background: It has been reported that patients with PD have autonomic dysfunction while no literature exists regarding autonomic function in ET. Methods: Subjects with PD, ET, and controls had autonomic function measured using the SCOPA-Autonomic questionnaire, with the total and domain scores transformed to a scale of 0-100 points. Results: 62 subjects with PD, 84 with ET, and 291 controls were included. Women were more prevalent in control (69%) compared to PD (44%) and ET (44%) groups, and mean age was significantly younger in PD (73 yrs) and older in ET (83) compared to controls (81). The mean SCOPA-Aut Total score in PD was significantly higher than controls, with no difference in ET. No autonomic dysfunction was found in any domain in ET but in PD there were significant abnormalities in gastrointestinal, cardiovascular, urinary, and thermoregulatory domains. Individual question data revealed a significantly higher percentage of subjects with dysfunction on 11/23 questions in the PD group but only 1 question (sialorrhea) in the ET group compared with controls. Conclusion: Autonomic scores, particularly gastrointestinal, cardiovascular, urinary, and thermoregulatory were increased in patients with PD, as assessed by SCOPA-Aut. Patients with ET did not exhibit autonomic dysfunction, with the exception of sialorrhea.

KW - Autonomic dysfunction

KW - Essential tremor

KW - Parkinson's disease

UR - http://www.scopus.com/inward/record.url?scp=84870504986&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870504986&partnerID=8YFLogxK

U2 - 10.1016/j.parkreldis.2012.06.008

DO - 10.1016/j.parkreldis.2012.06.008

M3 - Article

C2 - 22771283

AN - SCOPUS:84870504986

VL - 18

SP - 1089

EP - 1093

JO - Parkinsonism and Related Disorders

JF - Parkinsonism and Related Disorders

SN - 1353-8020

IS - 10

ER -