Autonomic dysfunction in patients with chronic intestinal pseudo-obstruction

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

We prospectively evaluated autonomic function in 50 patients with clinical and manometric features of a neuropathic form of chronic intestinal pseudo-obstruction (CIP). In 26 patients, there were underlying disease processes that may have affected extrinsic neural control to viscera: diabetes mellitus (n = 16), previous gastric surgery (n = 5), and other neurologic disorders (n = 5). Our aim was to characterize autonomic function in these patients, and those 24 with CIP unassociated with a known underlying neurologic disorder (idiopathic group). We assessed vagal function and sympathetic cholinergic and adrenergic function by means of standardized autonomic tests and quantitated postprandial antral pressure activity. We also measured postprandial levels of pancreatic polypeptide and neurotensin as indicators of vagal function and of the delivery of nutrients to the distal small bowel. Among the idiopathic group (n = 24), two had evidence of a generalized sympathetic neuropathy and five abdominal vagal dysfunction (one had both). Among diabetic patients, three had sympathetic adrenergic failure, six had orthostasis with normal plasma noradrenaline, ten had signs of generalized sympathetic neuropathy and eight had abdominal vagal dysfunction. Vagal dysfunction was identified in all three patients who underwent vagotomy as part of their previous gastric surgery. In the other neurologic syndromes, vagal function was abnormal in three of the five patients. Thus, autonomic and, particularly, vagal dysfunction are confirmed in a majority of patients with CIP associated with known diabetes or neurologic disorders; however, a previously unrecognized autonomic (chiefly vagal) neuropathy of undetermined cause has been identified in five of the 24 'idiopathic' CIP patients. Autonomic function should be evaluated in patients presenting with the syndrome of chronic intestinal pseudo-obstruction.

Original languageEnglish (US)
Pages (from-to)95-100
Number of pages6
JournalClinical Autonomic Research
Volume3
Issue number2
DOIs
StatePublished - 1993

Fingerprint

Intestinal Pseudo-Obstruction
Nervous System Diseases
Adrenergic Agents
Stomach
Pancreatic Polypeptide
Neurotensin
Viscera
Vagotomy
Dizziness
Cholinergic Agents
Nervous System
Norepinephrine
Diabetes Mellitus
Pressure
Food

Keywords

  • Dysautonomia
  • Dysmotility
  • Gastroparesis
  • Neurotensin
  • Pancreatic polypeptide
  • Pseudo-obstruction
  • Sympathetic
  • Vagus

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Autonomic dysfunction in patients with chronic intestinal pseudo-obstruction. / Camilleri, Michael; Balm, R. K.; Low, Phillip Anson.

In: Clinical Autonomic Research, Vol. 3, No. 2, 1993, p. 95-100.

Research output: Contribution to journalArticle

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