Autonomic correlates of orthostatic intolerance and seizures

V. Novak, P. Novak, A. Reeves, Phillip Anson Low

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

We describe an integrated evaluation of central autonomic regulation, relating the simultaneously recorded electroencephalogram (EEG) and transcranial Doppler (TCD) to systemic cardiovascular indices. Signal analysis techniques included time-frequency analysis and nonlinear rescaled range analysis. The inhibition of centrally mediated autonomic rhythms can precede clinical manifestations e.g. syncope (increased slow EEG modulation, withdrawal of 0.05 Hz rhythms in BP and progressive decline in total peripheral resistance). We tested the hypothesis that partial complex seizures, which has a structural substrate with powerful autonomic manifestations, might also have autonomic alterations that precede EEG changes. We observed that sympathetic activation of slow rhythms in RRI preceded seizure onset, while parasympathetically mediated rhythms rapidly diminished at the beginning of the seizure. We used the Hurst exponent, based on the rescaled range analysis for evaluation of deterministic component in patients with orthostatic tachycardia. Data showed that the loss of variability in RRI was associated with increased values of Hurst exponent. Thus, the process become more deterministic.

Original languageEnglish (US)
Title of host publicationStudies in Health Technology and Informatics
Pages189-208
Number of pages20
Volume60
DOIs
StatePublished - 1999

Fingerprint

Orthostatic Intolerance
Electroencephalography
Seizures
Signal analysis
Syncope
Tachycardia
Vascular Resistance
Chemical activation
Modulation
Substrates

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Health Information Management

Cite this

Novak, V., Novak, P., Reeves, A., & Low, P. A. (1999). Autonomic correlates of orthostatic intolerance and seizures. In Studies in Health Technology and Informatics (Vol. 60, pp. 189-208) https://doi.org/10.3233/978-1-60750-904-2-189

Autonomic correlates of orthostatic intolerance and seizures. / Novak, V.; Novak, P.; Reeves, A.; Low, Phillip Anson.

Studies in Health Technology and Informatics. Vol. 60 1999. p. 189-208.

Research output: Chapter in Book/Report/Conference proceedingChapter

Novak, V, Novak, P, Reeves, A & Low, PA 1999, Autonomic correlates of orthostatic intolerance and seizures. in Studies in Health Technology and Informatics. vol. 60, pp. 189-208. https://doi.org/10.3233/978-1-60750-904-2-189
Novak V, Novak P, Reeves A, Low PA. Autonomic correlates of orthostatic intolerance and seizures. In Studies in Health Technology and Informatics. Vol. 60. 1999. p. 189-208 https://doi.org/10.3233/978-1-60750-904-2-189
Novak, V. ; Novak, P. ; Reeves, A. ; Low, Phillip Anson. / Autonomic correlates of orthostatic intolerance and seizures. Studies in Health Technology and Informatics. Vol. 60 1999. pp. 189-208
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