TY - JOUR
T1 - Autonomic Cardiovascular Control in Health and Disease
AU - Karim, Shahid
AU - Chahal, Anwar
AU - Khanji, Mohammed Y.
AU - Petersen, Steffen E.
AU - Somers, Virend K.
N1 - Funding Information:
This work was supported by National Institutes of Health grant HL134885. The contents of this paper are solely the responsibility of the authors and do not necessarily represent the official view of the National Institutes of Health. All authors have reported that they have no other relationships relevant to the contents of this paper to disclose.
Publisher Copyright:
© American Physiological Society and Mayo Clinic.
PY - 2023/4
Y1 - 2023/4
N2 - Autonomic neural control of the cardiovascular system is formed of complex and dynamic processes able to adjust rapidly to mitigate perturbations in hemodynamics and maintain home-ostasis. Alterations in autonomic control feature in the development or progression of a multitude of diseases with wide-ranging physiological implications given the neural system’s responsibility for controlling inotropy, chronotropy, lusitropy, and dromotropy. Imbalances in sympathetic and parasympathetic neural control are also implicated in the development of arrhythmia in several cardiovascular conditions sparking interest in autonomic modulation as a form of treatment. A number of measures of autonomic function have shown prognostic significance in health and in pathological states and have undergone varying degrees of refinement, yet adoption into clinical practice remains extremely limited. The focus of this contemporary narrative review is to summarize the anatomy, physiology, and pathophysiology of the cardiovascular autonomic nervous system and describe the merits and shortfalls of testing modalities available.
AB - Autonomic neural control of the cardiovascular system is formed of complex and dynamic processes able to adjust rapidly to mitigate perturbations in hemodynamics and maintain home-ostasis. Alterations in autonomic control feature in the development or progression of a multitude of diseases with wide-ranging physiological implications given the neural system’s responsibility for controlling inotropy, chronotropy, lusitropy, and dromotropy. Imbalances in sympathetic and parasympathetic neural control are also implicated in the development of arrhythmia in several cardiovascular conditions sparking interest in autonomic modulation as a form of treatment. A number of measures of autonomic function have shown prognostic significance in health and in pathological states and have undergone varying degrees of refinement, yet adoption into clinical practice remains extremely limited. The focus of this contemporary narrative review is to summarize the anatomy, physiology, and pathophysiology of the cardiovascular autonomic nervous system and describe the merits and shortfalls of testing modalities available.
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U2 - 10.1002/cphy.c210037
DO - 10.1002/cphy.c210037
M3 - Article
C2 - 36994768
AN - SCOPUS:85151178610
SN - 2040-4603
VL - 13
SP - 4493
EP - 4511
JO - Comprehensive Physiology
JF - Comprehensive Physiology
IS - 2
ER -