AUTOMATED MICROFLUIDIC DEVICE FOR WHOLE BLOOD PLASMA SEPARATION AND BIOMARKERS ANALYSIS IN MICROLITER SAMPLES

Alan M. Gonzalez-Suarez, Gulnaz Stybayeva, William A. Carey, Alexander Revzin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The present work reports the development of a microfluidic platform that integrates plasma separation and a bioanalysis module to enable detection of several biomarkers from 5 µL of whole human blood. By incorporating active mixing, we improve reaction times compared to diffusion-based mixing. We tested the device with human whole blood samples, comparing plasma separation quality and a glucose assay using the microfluidic device and standard methods, showing that our microfluidic device can perform both steps using only minute blood samples.

Original languageEnglish (US)
Title of host publicationMicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages647-648
Number of pages2
ISBN (Electronic)9781733419031
StatePublished - 2021
Event25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 - Palm Springs, Virtual, United States
Duration: Oct 10 2021Oct 14 2021

Publication series

NameMicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
Country/TerritoryUnited States
CityPalm Springs, Virtual
Period10/10/2110/14/21

Keywords

  • active mixing
  • biomarkers analysis
  • plasma separation
  • whole blood

ASJC Scopus subject areas

  • Bioengineering
  • Chemical Engineering (miscellaneous)

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