Automated mapping of hippocampal atrophy in 1-year repeat MRI data from 490 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls.

Jonathan H. Morra, Zhuowen Tu, Liana G. Apostolova, Amity E. Green, Christina Avedissian, Sarah K. Madsen, Neelroop Parikshak, Arthur W. Toga, Clifford R Jr. Jack, Norbert Schuff, Michael W. Weiner, Paul M. Thompson

Research output: Contribution to journalArticle

167 Citations (Scopus)

Abstract

As one of the earliest structures to degenerate in Alzheimer's disease (AD), the hippocampus is the target of many studies of factors that influence rates of brain degeneration in the elderly. In one of the largest brain mapping studies to date, we mapped the 3D profile of hippocampal degeneration over time in 490 subjects scanned twice with brain MRI over a 1-year interval (980 scans). We examined baseline and 1-year follow-up scans of 97 AD subjects (49 males/48 females), 148 healthy control subjects (75 males/73 females), and 245 subjects with mild cognitive impairment (MCI; 160 males/85 females). We used our previously validated automated segmentation method, based on AdaBoost, to create 3D hippocampal surface models in all 980 scans. Hippocampal volume loss rates increased with worsening diagnosis (normal=0.66%/year; MCI=3.12%/year; AD=5.59%/year), and correlated with both baseline and interval changes in Mini-Mental State Examination (MMSE) scores and global and sum-of-boxes Clinical Dementia Rating scale (CDR) scores. Surface-based statistical maps visualized a selective profile of ongoing atrophy in all three diagnostic groups. Healthy controls carrying the ApoE4 gene atrophied faster than non-carriers, while more educated controls atrophied more slowly; converters from MCI to AD showed faster atrophy than non-converters. Hippocampal loss rates can be rapidly mapped, and they track cognitive decline closely enough to be used as surrogate markers of Alzheimer's disease in drug trials. They also reveal genetically greater atrophy in cognitively intact subjects.

Original languageEnglish (US)
JournalNeuroImage
Volume45
Issue number1 Suppl
DOIs
StatePublished - Mar 2009

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Atrophy
Alzheimer Disease
Brain Mapping
Apolipoprotein E4
Brain
Dementia
Hippocampus
Healthy Volunteers
Biomarkers
Cognitive Dysfunction
Pharmaceutical Preparations
Genes

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

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Automated mapping of hippocampal atrophy in 1-year repeat MRI data from 490 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls. / Morra, Jonathan H.; Tu, Zhuowen; Apostolova, Liana G.; Green, Amity E.; Avedissian, Christina; Madsen, Sarah K.; Parikshak, Neelroop; Toga, Arthur W.; Jack, Clifford R Jr.; Schuff, Norbert; Weiner, Michael W.; Thompson, Paul M.

In: NeuroImage, Vol. 45, No. 1 Suppl, 03.2009.

Research output: Contribution to journalArticle

Morra, JH, Tu, Z, Apostolova, LG, Green, AE, Avedissian, C, Madsen, SK, Parikshak, N, Toga, AW, Jack, CRJ, Schuff, N, Weiner, MW & Thompson, PM 2009, 'Automated mapping of hippocampal atrophy in 1-year repeat MRI data from 490 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls.', NeuroImage, vol. 45, no. 1 Suppl. https://doi.org/10.1016/j.neuroimage.2008.10.043
Morra, Jonathan H. ; Tu, Zhuowen ; Apostolova, Liana G. ; Green, Amity E. ; Avedissian, Christina ; Madsen, Sarah K. ; Parikshak, Neelroop ; Toga, Arthur W. ; Jack, Clifford R Jr. ; Schuff, Norbert ; Weiner, Michael W. ; Thompson, Paul M. / Automated mapping of hippocampal atrophy in 1-year repeat MRI data from 490 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls. In: NeuroImage. 2009 ; Vol. 45, No. 1 Suppl.
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