@article{63b76c55041047e69d7b2262dd9ef042,
title = "Automated 3D mapping of baseline and 12-month associations between three verbal memory measures and hippocampal atrophy in 490 ADNI subjects",
abstract = "We used a previously validated automated machine learning algorithm based on adaptive boosting to segment the hippocampi in baseline and 12-month follow-up 3D T1-weighted brain MRIs of 150 cognitively normal elderly (NC), 245 mild cognitive impairment (MCI) and 97 Dementia of the Alzheimer's type (DAT) ADNI subjects. Using the radial distance mapping technique, we examined the hippocampal correlates of delayed recall performance on three well-established verbal memory tests-ADAScog delayed recall (ADAScog-DR), the Rey Auditory Verbal Learning Test -DR (AVLT-DR) and Wechsler Logical Memory II-DR (LM II-DR). We observed no significant correlations between delayed recall performance and hippocampal radial distance on any of the three verbal memory measures in NC. All three measures were associated with hippocampal volumes and radial distance in the full sample and in the MCI group at baseline and at follow-up. In DAT we observed stronger left-sided associations between hippocampal radial distance, LM II-DR and ADAScog-DR both at baseline and at follow-up. The strongest linkage between memory performance and hippocampal atrophy in the MCI sample was observed with the most challenging verbal memory test-the AVLT-DR, as opposed to the DAT sample where the least challenging test the ADAScog-DR showed strongest associations with the hippocampal structure. After controlling for baseline hippocampal atrophy, memory performance showed regionally specific associations with hippocampal radial distance in predominantly CA1 but also in subicular distribution.",
author = "Apostolova, {Liana G.} and Morra, {Jonathan H.} and Green, {Amity E.} and Hwang, {Kristy S.} and Christina Avedissian and Ellen Woo and Cummings, {Jeffrey L.} and Toga, {Arthur W.} and Jack, {Clifford R.} and Weiner, {Michael W.} and Thompson, {Paul M.}",
note = "Funding Information: Data used in preparing this article were obtained from the Alzheimer's Disease Neuroimaging Initiative database ( www.loni.ucla.edu/ADNI ). Many ADNI investigators therefore contributed to the design and implementation of ADNI or provided data but did not participate in the analysis or writing of this report. A complete listing of ADNI investigators is available at www.loni.ucla.edu/ADNI /Collaboration/ADNI_Citation.shtml. All data collection was funded by the following ADNI funding sources (Principal Investigator: Michael Weiner; NIH grant number U01 AG024904 ): National Institute of Aging (NIA), the National Institute of Biomedical Imaging and Bioengineering (NIBIB), the Foundation for the National Institutes of Health, Pfizer Inc., Wyeth Research, Bristol-Myers Squibb, Eli Lilly and Company, GlaxoSmithKline, Merck & Co. Inc., AstraZeneca AB, Novartis Pharmaceuticals Corporation, the Alzheimer's Association, Eisai Global Clinical Development, Elan Corporation plc, Forest Laboratories, and the Institute for the Study of Aging (ISOA), with participation from the U.S. Food and Drug Administration. The grantee organization is the Northern California Institute for Research and Education, and the study is coordinated by the Alzheimer's Disease Cooperative Study at the University of California, San Diego. We thank the members of the ADNI Imaging Core for their contributions to the image pre-processing and the ADNI project. Funding Information: All study analyses were funded by NIA K23 AG026803 (jointly sponsored by NIA, AFAR, The John A. Hartford Foundation, The Atlantic Philanthropies, The Starr Foundation and an anonymous donor; to LGA), the Turken Foundation (to LGA); NIA P 50 AG16570 (to LGA, JLC and PMT); NIBIB EB01651, NLM LM05639, NCRR RR019771 (to PMT); and NIMH R01 MH071940, NCRR P41 RR013642 and NIH U54 RR021813 (to AWT). ",
year = "2010",
month = may,
doi = "10.1016/j.neuroimage.2009.12.125",
language = "English (US)",
volume = "51",
pages = "488--499",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",
number = "1",
}