Autologous stem cell transplant for immunoglobulin light chain amyloidosis: A status report

Morie A. Gertz, Martha Q. Lacy, Angela Dispenzieri, Suzanne R. Hayman, Shaji K. Kumar, David Dingli, Stephen M. Ansell, Dennis A. Gastineau, David J. Inwards, Patrick B. Johnston, Mark R. Litzow, Ivana N.M. Micallef, Luis F. Porrata, Nelson Leung, William J. Hogan, Francis K. Buadi

Research output: Contribution to journalArticle

78 Scopus citations

Abstract

High-dose chemotherapy for the management of immunoglobulin light chain amyloidosis remains an effective and viable treatment technique for selected patients with this disorder. We reviewed the medical records of 434 patients uniformly treated with high-dose chemotherapy and autologous stem cell transplant at Mayo Clinic, Rochester, Minnesota, between 8 March 1996 and 13 April 2010. Outcomes, engraftment, and predictors of early mortality were reviewed. Median survival has not been reached for the patients with a complete response, is 107 months for those with a partial response, and is 32 months for patients with no response (p<0.001). The only predictor of survival was cardiac stage (p <0.001). The hematologic response rate is predictive for organ response rates. Both hematologic and organ responses are associated with improved survival.

Original languageEnglish (US)
Pages (from-to)2181-2187
Number of pages7
JournalLeukemia and Lymphoma
Volume51
Issue number12
DOIs
StatePublished - Dec 1 2010

Keywords

  • Amyloidosis
  • multiple myeloma
  • nephrotic syndrome
  • restrictive cardiomyopathy
  • stem cell transplant

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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