Autologous Mesenchymal Stem Cells, Applied in a Bioabsorbable Matrix, for Treatment of Perianal Fistulas in Patients With Crohn's Disease

Allan B Dietz, Eric Dozois, Joel Garland Fletcher, Greg W. Butler, Darcie Radel, Amy Lightner, Maneesh Dave, Jessica Friton, Asha Nair, Emily T. Camilleri, Amel Dudakovic, Andre J van Wijnen, William Alvis Faubion

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

In patients with Crohn's disease, perianal fistulas recur frequently, causing substantial morbidity. We performed a 12-patient, 6-month, phase 1 trial to determine whether autologous mesenchymal stem cells, applied in a bioabsorbable matrix, can heal the fistula. Fistula repair was not associated with any serious adverse events related to mesenchymal stem cells or plug placement. At 6 months, 10 of 12 patients (83%) had complete clinical healing and radiographic markers of response. We found placement of mesenchymal stem cell−coated matrix fistula plugs in 12 patients with chronic perianal fistulas to be safe and lead to clinical healing and radiographic response in 10 patients. ClinicalTrials.gov Identifier: NCT01915927.

Original languageEnglish (US)
Pages (from-to)59-62.e2
JournalGastroenterology
Volume153
Issue number1
DOIs
StatePublished - Jul 1 2017

Fingerprint

Mesenchymal Stromal Cells
Crohn Disease
Fistula
Therapeutics
Morbidity

Keywords

  • Cell Therapy
  • Clinical Trial
  • IBD
  • STOMP Trial

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Autologous Mesenchymal Stem Cells, Applied in a Bioabsorbable Matrix, for Treatment of Perianal Fistulas in Patients With Crohn's Disease. / Dietz, Allan B; Dozois, Eric; Fletcher, Joel Garland; Butler, Greg W.; Radel, Darcie; Lightner, Amy; Dave, Maneesh; Friton, Jessica; Nair, Asha; Camilleri, Emily T.; Dudakovic, Amel; van Wijnen, Andre J; Faubion, William Alvis.

In: Gastroenterology, Vol. 153, No. 1, 01.07.2017, p. 59-62.e2.

Research output: Contribution to journalArticle

Dietz, Allan B ; Dozois, Eric ; Fletcher, Joel Garland ; Butler, Greg W. ; Radel, Darcie ; Lightner, Amy ; Dave, Maneesh ; Friton, Jessica ; Nair, Asha ; Camilleri, Emily T. ; Dudakovic, Amel ; van Wijnen, Andre J ; Faubion, William Alvis. / Autologous Mesenchymal Stem Cells, Applied in a Bioabsorbable Matrix, for Treatment of Perianal Fistulas in Patients With Crohn's Disease. In: Gastroenterology. 2017 ; Vol. 153, No. 1. pp. 59-62.e2.
@article{95664e352ba4403695dabd04b789e0f4,
title = "Autologous Mesenchymal Stem Cells, Applied in a Bioabsorbable Matrix, for Treatment of Perianal Fistulas in Patients With Crohn's Disease",
abstract = "In patients with Crohn's disease, perianal fistulas recur frequently, causing substantial morbidity. We performed a 12-patient, 6-month, phase 1 trial to determine whether autologous mesenchymal stem cells, applied in a bioabsorbable matrix, can heal the fistula. Fistula repair was not associated with any serious adverse events related to mesenchymal stem cells or plug placement. At 6 months, 10 of 12 patients (83{\%}) had complete clinical healing and radiographic markers of response. We found placement of mesenchymal stem cell−coated matrix fistula plugs in 12 patients with chronic perianal fistulas to be safe and lead to clinical healing and radiographic response in 10 patients. ClinicalTrials.gov Identifier: NCT01915927.",
keywords = "Cell Therapy, Clinical Trial, IBD, STOMP Trial",
author = "Dietz, {Allan B} and Eric Dozois and Fletcher, {Joel Garland} and Butler, {Greg W.} and Darcie Radel and Amy Lightner and Maneesh Dave and Jessica Friton and Asha Nair and Camilleri, {Emily T.} and Amel Dudakovic and {van Wijnen}, {Andre J} and Faubion, {William Alvis}",
year = "2017",
month = "7",
day = "1",
doi = "10.1053/j.gastro.2017.04.001",
language = "English (US)",
volume = "153",
pages = "59--62.e2",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Autologous Mesenchymal Stem Cells, Applied in a Bioabsorbable Matrix, for Treatment of Perianal Fistulas in Patients With Crohn's Disease

AU - Dietz, Allan B

AU - Dozois, Eric

AU - Fletcher, Joel Garland

AU - Butler, Greg W.

AU - Radel, Darcie

AU - Lightner, Amy

AU - Dave, Maneesh

AU - Friton, Jessica

AU - Nair, Asha

AU - Camilleri, Emily T.

AU - Dudakovic, Amel

AU - van Wijnen, Andre J

AU - Faubion, William Alvis

PY - 2017/7/1

Y1 - 2017/7/1

N2 - In patients with Crohn's disease, perianal fistulas recur frequently, causing substantial morbidity. We performed a 12-patient, 6-month, phase 1 trial to determine whether autologous mesenchymal stem cells, applied in a bioabsorbable matrix, can heal the fistula. Fistula repair was not associated with any serious adverse events related to mesenchymal stem cells or plug placement. At 6 months, 10 of 12 patients (83%) had complete clinical healing and radiographic markers of response. We found placement of mesenchymal stem cell−coated matrix fistula plugs in 12 patients with chronic perianal fistulas to be safe and lead to clinical healing and radiographic response in 10 patients. ClinicalTrials.gov Identifier: NCT01915927.

AB - In patients with Crohn's disease, perianal fistulas recur frequently, causing substantial morbidity. We performed a 12-patient, 6-month, phase 1 trial to determine whether autologous mesenchymal stem cells, applied in a bioabsorbable matrix, can heal the fistula. Fistula repair was not associated with any serious adverse events related to mesenchymal stem cells or plug placement. At 6 months, 10 of 12 patients (83%) had complete clinical healing and radiographic markers of response. We found placement of mesenchymal stem cell−coated matrix fistula plugs in 12 patients with chronic perianal fistulas to be safe and lead to clinical healing and radiographic response in 10 patients. ClinicalTrials.gov Identifier: NCT01915927.

KW - Cell Therapy

KW - Clinical Trial

KW - IBD

KW - STOMP Trial

UR - http://www.scopus.com/inward/record.url?scp=85020942961&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020942961&partnerID=8YFLogxK

U2 - 10.1053/j.gastro.2017.04.001

DO - 10.1053/j.gastro.2017.04.001

M3 - Article

C2 - 28400193

AN - SCOPUS:85020942961

VL - 153

SP - 59-62.e2

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 1

ER -