Autologous Mesenchymal Stem Cells, Applied in a Bioabsorbable Matrix, for Treatment of Perianal Fistulas in Patients With Crohn's Disease

Allan B. Dietz; Eric J. Dozois; Joel G. Fletcher; Greg W. Butler; Darcie Radel; Amy L. Lightner; Maneesh Dave; Jessica Friton; Asha Nair; Emily T. Camilleri; Amel Dudakovic; Andre J. van Wijnen; William A. Faubion

doi:10.1053/j.gastro.2017.04.001

Autologous Mesenchymal Stem Cells, Applied in a Bioabsorbable Matrix, for Treatment of Perianal Fistulas in Patients With Crohn's Disease

Allan B. Dietz, Eric J. Dozois, Joel G. Fletcher, Greg W. Butler, Darcie Radel, Amy L. Lightner, Maneesh Dave, Jessica Friton, Asha Nair, Emily T. Camilleri, Amel Dudakovic, Andre J. van Wijnen, William A. Faubion

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75 Scopus citations

Abstract

In patients with Crohn's disease, perianal fistulas recur frequently, causing substantial morbidity. We performed a 12-patient, 6-month, phase 1 trial to determine whether autologous mesenchymal stem cells, applied in a bioabsorbable matrix, can heal the fistula. Fistula repair was not associated with any serious adverse events related to mesenchymal stem cells or plug placement. At 6 months, 10 of 12 patients (83%) had complete clinical healing and radiographic markers of response. We found placement of mesenchymal stem cell−coated matrix fistula plugs in 12 patients with chronic perianal fistulas to be safe and lead to clinical healing and radiographic response in 10 patients. ClinicalTrials.gov Identifier: NCT01915927.

Original language	English (US)
Pages (from-to)	59-62.e2
Journal	Gastroenterology
Volume	153
Issue number	1
DOIs	https://doi.org/10.1053/j.gastro.2017.04.001
State	Published - Jul 2017

Keywords

Cell Therapy
Clinical Trial
IBD
STOMP Trial

ASJC Scopus subject areas

Hepatology
Gastroenterology

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10.1053/j.gastro.2017.04.001

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Dietz, A. B., Dozois, E. J., Fletcher, J. G., Butler, G. W., Radel, D., Lightner, A. L., Dave, M., Friton, J., Nair, A., Camilleri, E. T., Dudakovic, A., van Wijnen, A. J., & Faubion, W. A. (2017). Autologous Mesenchymal Stem Cells, Applied in a Bioabsorbable Matrix, for Treatment of Perianal Fistulas in Patients With Crohn's Disease. Gastroenterology, 153(1), 59-62.e2. https://doi.org/10.1053/j.gastro.2017.04.001

Dietz, AB , Dozois, EJ , Fletcher, JG, Butler, GW, Radel, D, Lightner, AL, Dave, M, Friton, J, Nair, A, Camilleri, ET, Dudakovic, A, van Wijnen, AJ & Faubion, WA 2017, 'Autologous Mesenchymal Stem Cells, Applied in a Bioabsorbable Matrix, for Treatment of Perianal Fistulas in Patients With Crohn's Disease', Gastroenterology, vol. 153, no. 1, pp. 59-62.e2. https://doi.org/10.1053/j.gastro.2017.04.001

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title = "Autologous Mesenchymal Stem Cells, Applied in a Bioabsorbable Matrix, for Treatment of Perianal Fistulas in Patients With Crohn's Disease",

abstract = "In patients with Crohn's disease, perianal fistulas recur frequently, causing substantial morbidity. We performed a 12-patient, 6-month, phase 1 trial to determine whether autologous mesenchymal stem cells, applied in a bioabsorbable matrix, can heal the fistula. Fistula repair was not associated with any serious adverse events related to mesenchymal stem cells or plug placement. At 6 months, 10 of 12 patients (83%) had complete clinical healing and radiographic markers of response. We found placement of mesenchymal stem cell−coated matrix fistula plugs in 12 patients with chronic perianal fistulas to be safe and lead to clinical healing and radiographic response in 10 patients. ClinicalTrials.gov Identifier: NCT01915927.",

keywords = "Cell Therapy, Clinical Trial, IBD, STOMP Trial",

author = "Dietz, {Allan B.} and Dozois, {Eric J.} and Fletcher, {Joel G.} and Butler, {Greg W.} and Darcie Radel and Lightner, {Amy L.} and Maneesh Dave and Jessica Friton and Asha Nair and Camilleri, {Emily T.} and Amel Dudakovic and {van Wijnen}, {Andre J.} and Faubion, {William A.}",

note = "Publisher Copyright: {\textcopyright} 2017 AGA Institute",

year = "2017",

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doi = "10.1053/j.gastro.2017.04.001",

language = "English (US)",

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AU - Dozois, Eric J.

AU - Fletcher, Joel G.

AU - Butler, Greg W.

AU - Radel, Darcie

AU - Lightner, Amy L.

AU - Dave, Maneesh

AU - Friton, Jessica

AU - Nair, Asha

AU - Camilleri, Emily T.

AU - Dudakovic, Amel

AU - van Wijnen, Andre J.

AU - Faubion, William A.

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AB - In patients with Crohn's disease, perianal fistulas recur frequently, causing substantial morbidity. We performed a 12-patient, 6-month, phase 1 trial to determine whether autologous mesenchymal stem cells, applied in a bioabsorbable matrix, can heal the fistula. Fistula repair was not associated with any serious adverse events related to mesenchymal stem cells or plug placement. At 6 months, 10 of 12 patients (83%) had complete clinical healing and radiographic markers of response. We found placement of mesenchymal stem cell−coated matrix fistula plugs in 12 patients with chronic perianal fistulas to be safe and lead to clinical healing and radiographic response in 10 patients. ClinicalTrials.gov Identifier: NCT01915927.

KW - Cell Therapy

KW - Clinical Trial

KW - IBD

KW - STOMP Trial

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Autologous Mesenchymal Stem Cells, Applied in a Bioabsorbable Matrix, for Treatment of Perianal Fistulas in Patients With Crohn's Disease

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Keywords

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