Autologous Conditioned Serum

Christopher H. Evans; Xavier Chevalier; Peter Wehling

doi:10.1016/j.pmr.2016.06.003

Autologous Conditioned Serum

Christopher H. Evans, Xavier Chevalier, Peter Wehling

Physical Medicine and Rehabilitation

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

Autologous conditioned serum was developed in the mid 1990s as an expeditious, practical, and relatively inexpensive means of generating the interleukin-1 receptor antagonist, a naturally occurring inhibitor of the cytokine interleukin-1. The latter is thought to be an important mediator of inflammation, pain, and tissue destruction in musculoskeletal conditions. ACS has been widely and successfully used in the local treatment of human and equine osteoarthritis and radicular compression; it has also shown promise in treating tendinopathies, muscle injuries, and tunnel widening after reconstruction of the anterior cruciate ligament. Experience suggests that autologous conditioned serum is safe and effective.

Original language	English (US)
Pages (from-to)	893-908
Number of pages	16
Journal	Physical Medicine and Rehabilitation Clinics of North America
Volume	27
Issue number	4
DOIs	https://doi.org/10.1016/j.pmr.2016.06.003
State	Published - Nov 1 2016

Keywords

Anterior cruciate ligament
Interleukin-1 receptor antagonist
Intra-articular therapy
Muscle injury
Osteoarthritis
Pain
Radicular compression
Tendinopathy

ASJC Scopus subject areas

Physical Therapy, Sports Therapy and Rehabilitation
Rehabilitation

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10.1016/j.pmr.2016.06.003

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title = "Autologous Conditioned Serum",

abstract = "Autologous conditioned serum was developed in the mid 1990s as an expeditious, practical, and relatively inexpensive means of generating the interleukin-1 receptor antagonist, a naturally occurring inhibitor of the cytokine interleukin-1. The latter is thought to be an important mediator of inflammation, pain, and tissue destruction in musculoskeletal conditions. ACS has been widely and successfully used in the local treatment of human and equine osteoarthritis and radicular compression; it has also shown promise in treating tendinopathies, muscle injuries, and tunnel widening after reconstruction of the anterior cruciate ligament. Experience suggests that autologous conditioned serum is safe and effective.",

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AU - Wehling, Peter

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AB - Autologous conditioned serum was developed in the mid 1990s as an expeditious, practical, and relatively inexpensive means of generating the interleukin-1 receptor antagonist, a naturally occurring inhibitor of the cytokine interleukin-1. The latter is thought to be an important mediator of inflammation, pain, and tissue destruction in musculoskeletal conditions. ACS has been widely and successfully used in the local treatment of human and equine osteoarthritis and radicular compression; it has also shown promise in treating tendinopathies, muscle injuries, and tunnel widening after reconstruction of the anterior cruciate ligament. Experience suggests that autologous conditioned serum is safe and effective.

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KW - Pain

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Autologous Conditioned Serum

Abstract

Keywords

ASJC Scopus subject areas

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