Autoimmune pathogenesis of paraneoplastic neurological syndromes.

N. E. Anderson, Julie M Cunningham, J. B. Posner

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

"Remote effects" of cancer on the nervous system (paraneoplastic syndromes) are disorders of the nervous system of unknown cause that occur almost exclusively, or with greatly increased frequency, in patients with identifiable or occult cancer. There are several hypotheses concerning the pathogenesis of these rare disorders. One hypothesis is that the underlying tumor and portions of the nervous system share antigens and that an autoimmune response generated against the tumor causes the nervous system disorder. Evidence supporting this hypothesis includes the ability to transmit the Lambert-Eaton Syndrome (a paraneoplastic syndrome involving the neuromuscular junction) to experimental animals by infusing IgG from patients with the disorder, the presence of autoantibodies against Purkinje cell neurons in some patients with paraneoplastic cerebellar degeneration, and the presence of autoantibodies against many neurons in patients with sensory neuronopathy and encephalomyelitis. Other evidence supporting the hypothesis is presented in this review.

Original languageEnglish (US)
Pages (from-to)245-299
Number of pages55
JournalCritical Reviews in Neurobiology
Volume3
Issue number3
StatePublished - 1987
Externally publishedYes

Fingerprint

Paraneoplastic Syndromes
Nervous System Neoplasms
Purkinje Cells
Nervous System Diseases
Autoantibodies
Nervous System Paraneoplastic Syndromes
Paraneoplastic Cerebellar Degeneration
Lambert-Eaton Myasthenic Syndrome
Encephalomyelitis
Neuromuscular Junction
Autoimmunity
Neoplasms
Immunoglobulin G
Neurons
Antigens

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Autoimmune pathogenesis of paraneoplastic neurological syndromes. / Anderson, N. E.; Cunningham, Julie M; Posner, J. B.

In: Critical Reviews in Neurobiology, Vol. 3, No. 3, 1987, p. 245-299.

Research output: Contribution to journalArticle

@article{d2435f49b67a4074962cd7a003628322,
title = "Autoimmune pathogenesis of paraneoplastic neurological syndromes.",
abstract = "{"}Remote effects{"} of cancer on the nervous system (paraneoplastic syndromes) are disorders of the nervous system of unknown cause that occur almost exclusively, or with greatly increased frequency, in patients with identifiable or occult cancer. There are several hypotheses concerning the pathogenesis of these rare disorders. One hypothesis is that the underlying tumor and portions of the nervous system share antigens and that an autoimmune response generated against the tumor causes the nervous system disorder. Evidence supporting this hypothesis includes the ability to transmit the Lambert-Eaton Syndrome (a paraneoplastic syndrome involving the neuromuscular junction) to experimental animals by infusing IgG from patients with the disorder, the presence of autoantibodies against Purkinje cell neurons in some patients with paraneoplastic cerebellar degeneration, and the presence of autoantibodies against many neurons in patients with sensory neuronopathy and encephalomyelitis. Other evidence supporting the hypothesis is presented in this review.",
author = "Anderson, {N. E.} and Cunningham, {Julie M} and Posner, {J. B.}",
year = "1987",
language = "English (US)",
volume = "3",
pages = "245--299",
journal = "Critical Reviews in Neurobiology",
issn = "0892-0915",
publisher = "Begell House Inc.",
number = "3",

}

TY - JOUR

T1 - Autoimmune pathogenesis of paraneoplastic neurological syndromes.

AU - Anderson, N. E.

AU - Cunningham, Julie M

AU - Posner, J. B.

PY - 1987

Y1 - 1987

N2 - "Remote effects" of cancer on the nervous system (paraneoplastic syndromes) are disorders of the nervous system of unknown cause that occur almost exclusively, or with greatly increased frequency, in patients with identifiable or occult cancer. There are several hypotheses concerning the pathogenesis of these rare disorders. One hypothesis is that the underlying tumor and portions of the nervous system share antigens and that an autoimmune response generated against the tumor causes the nervous system disorder. Evidence supporting this hypothesis includes the ability to transmit the Lambert-Eaton Syndrome (a paraneoplastic syndrome involving the neuromuscular junction) to experimental animals by infusing IgG from patients with the disorder, the presence of autoantibodies against Purkinje cell neurons in some patients with paraneoplastic cerebellar degeneration, and the presence of autoantibodies against many neurons in patients with sensory neuronopathy and encephalomyelitis. Other evidence supporting the hypothesis is presented in this review.

AB - "Remote effects" of cancer on the nervous system (paraneoplastic syndromes) are disorders of the nervous system of unknown cause that occur almost exclusively, or with greatly increased frequency, in patients with identifiable or occult cancer. There are several hypotheses concerning the pathogenesis of these rare disorders. One hypothesis is that the underlying tumor and portions of the nervous system share antigens and that an autoimmune response generated against the tumor causes the nervous system disorder. Evidence supporting this hypothesis includes the ability to transmit the Lambert-Eaton Syndrome (a paraneoplastic syndrome involving the neuromuscular junction) to experimental animals by infusing IgG from patients with the disorder, the presence of autoantibodies against Purkinje cell neurons in some patients with paraneoplastic cerebellar degeneration, and the presence of autoantibodies against many neurons in patients with sensory neuronopathy and encephalomyelitis. Other evidence supporting the hypothesis is presented in this review.

UR - http://www.scopus.com/inward/record.url?scp=0023494397&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023494397&partnerID=8YFLogxK

M3 - Article

C2 - 3315239

AN - SCOPUS:0023494397

VL - 3

SP - 245

EP - 299

JO - Critical Reviews in Neurobiology

JF - Critical Reviews in Neurobiology

SN - 0892-0915

IS - 3

ER -