Abstract
Autoimmune Pancreatitis (AIP) is a recently recognized chronic fibro-inflammatory disease of the pancreas. Although rare, its recognition continues to increase worldwide. Patients often present with painless obstructive jaundice mimicking pancreatic cancer. Two subtypes of AIP are known-type 1 is a multi-organ disease associated with IgG4; type 2 appears to be a pancreas-specific disorder. Dramatic response to steroid treatment is characteristic of both forms. A non-invasive diagnosis of type 1 AIP may be possible using diagnostic criteria (in ~70% cases) while diagnosis of type 2 requires histology. These subtypes differ in natural history- type 1 often relapses while initial reports suggest that type 2 does not. Long term complications include endocrine and exocrine insufficiency and in case of type 1, disease relapses and complications from extra-pancreatic involvement. Neither form affects long term survival. The treatment and follow-up guidelines continue to evolve with our increasing experience in AIP.
Original language | English (US) |
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Pages (from-to) | 95-105 |
Number of pages | 11 |
Journal | Current gastroenterology reports |
Volume | 14 |
Issue number | 2 |
DOIs | |
State | Published - Apr 2012 |
Keywords
- Autoimmune pancreatitis
- Chronic pancreatitis
- Idiopathic duct centric pancreatitis
- IgG4-related systemic disease
- Lymphoplasmacytic sclerosing pancreatitis
ASJC Scopus subject areas
- Gastroenterology