Autoimmune pancreatitis

Aravind Sugumar, Suresh T Chari

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The purpose of this review is to provide a concise view of the existing knowledge of autoimmune pancreatitis (AIP) for practicing clinicians. AIP is a rare disease whose recognition and understanding are evolving. It is a type of chronic pancreatitis that often presents as obstructive jaundice, has a distinctive histology, and is exquisitely sensitive to steroid therapy. This form of chronic pancreatitis has a unique clinical, biochemical, and radiological profile. The term "AIP" encompasses two subtypes: types 1 and 2. Type 1 AIP is the pancreatic manifestation of a systemic fibro-inflammatory disease called immunoglobulin G4-associated systemic diseases. Type 2 AIP has been shown to be associated with inflammatory bowel disease. Existing criteria are geared towards the diagnosis of type 1 AIP. At present, pancreatic histology is a requirement for the definitive diagnosis of type 2 AIP. AIP can mimic most other pancreatic diseases in its presentation, but in clinical practice, it often has to be differentiated from pancreatic cancer. There are established criteria and algorithms not only to diagnose AIP, but also to differentiate it from pancreatic cancer. The utility of these algorithms and the approach to management are discussed here.

Original languageEnglish (US)
Pages (from-to)1368-1373
Number of pages6
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume26
Issue number9
DOIs
StatePublished - 2011

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Pancreatitis
Chronic Pancreatitis
Pancreatic Neoplasms
Histology
Pancreatic Diseases
Obstructive Jaundice
Rare Diseases
Inflammatory Bowel Diseases
Immunoglobulins
Steroids

Keywords

  • Autoimmune pancreatitis
  • Chronic pancreatitis
  • Lymphoplasmacytic sclerosing pancreatitis
  • Pancreatic cancer

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Autoimmune pancreatitis. / Sugumar, Aravind; Chari, Suresh T.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 26, No. 9, 2011, p. 1368-1373.

Research output: Contribution to journalArticle

Sugumar, Aravind ; Chari, Suresh T. / Autoimmune pancreatitis. In: Journal of Gastroenterology and Hepatology (Australia). 2011 ; Vol. 26, No. 9. pp. 1368-1373.
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