Autoimmune myelopathies

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The differential diagnosis of inflammatory myelopathies is broad. Autoimmune myelopathies represent a heterogeneous but significant portion of inflammatory myelopathies. The discovery of serologic biomarkers of autoimmune myelopathies (including aquaporin-4 and collapsin response-mediator protein-5 [CRMP-5] immunoglobulin [Ig]Gs) supports the concept of an autoimmune attack targeting the spinal cord. Neuroimaging, in particular MRI, may reveal distinctive patterns of signal abnormality suggesting an autoimmune etiology, such as longitudinally extensive transverse myelitis in neuromyelitis optica spectrumdisorders or tract-specific changes in paraneoplastic disorders. IgG biomarkers of autoimmune myelopathies enable more precise disease classification and have the potential to direct a cancer search, predict outcome, guide therapeutic decision making, and lead to future development of antigen-specific targeted therapies. The goal of initial immunotherapy is to reverse or halt progression. Long-term immunotherapy aims to maintain remission and prevent relapse.

Original languageEnglish (US)
Pages (from-to)776-799
Number of pages24
JournalCONTINUUM Lifelong Learning in Neurology
Volume17
Issue number4
StatePublished - Aug 2011

Fingerprint

Spinal Cord Diseases
Myelitis
Immunotherapy
Biomarkers
Semaphorin-3A
Transverse Myelitis
Aquaporin 4
Neuromyelitis Optica
Neuroimaging
Immunoglobulins
Spinal Cord
Decision Making
Differential Diagnosis
Immunoglobulin G
Antigens
Recurrence
Therapeutics
Neoplasms
Proteins

ASJC Scopus subject areas

  • Clinical Neurology
  • Genetics(clinical)

Cite this

Autoimmune myelopathies. / Flanagan, Eoin; Lennon, Vanda A; Pittock, Sean J.

In: CONTINUUM Lifelong Learning in Neurology, Vol. 17, No. 4, 08.2011, p. 776-799.

Research output: Contribution to journalArticle

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