Autoimmune murine thyroiditis. V. Genetic influence on the disease in BSVS and BRVR mice

N. R. Rose; A. O. Vladutiu; C. S. David; D. C. Shreffler

Autoimmune murine thyroiditis. V. Genetic influence on the disease in BSVS and BRVR mice

N. R. Rose, A. O. Vladutiu, C. S. David, D. C. Shreffler

Immunology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Two inbred strains of mice, BSVS and BRVR, are similar in their antibody response to thyroglobulin but differ significantly with respect to thyroid gland damage. F₁ hybrids, like BSVS mice, respond well to thyroglobulin, exhibiting extensive thyroid lesions, whereas BRVR mice show minimal thyroid damage. H 2 typing of the two strains showed that BSVS mice have a type similar to H 2th, with the H 2D end of H 2d and the H 2K end of H 2s, whereas BRVR mice are H 2k. The cellular response to thyroglobulin appears to be influenced by a specific immune response gene located near the K end of the H 2 complex.

Original language	English (US)
Pages (from-to)	281-287
Number of pages	7
Journal	Clinical and Experimental Immunology
Volume	15
Issue number	2
State	Published - 1973

ASJC Scopus subject areas

General Medicine

Cite this

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title = "Autoimmune murine thyroiditis. V. Genetic influence on the disease in BSVS and BRVR mice",

abstract = "Two inbred strains of mice, BSVS and BRVR, are similar in their antibody response to thyroglobulin but differ significantly with respect to thyroid gland damage. F1 hybrids, like BSVS mice, respond well to thyroglobulin, exhibiting extensive thyroid lesions, whereas BRVR mice show minimal thyroid damage. H 2 typing of the two strains showed that BSVS mice have a type similar to H 2th, with the H 2D end of H 2d and the H 2K end of H 2s, whereas BRVR mice are H 2k. The cellular response to thyroglobulin appears to be influenced by a specific immune response gene located near the K end of the H 2 complex.",

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year = "1973",

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AU - Shreffler, D. C.

PY - 1973

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AB - Two inbred strains of mice, BSVS and BRVR, are similar in their antibody response to thyroglobulin but differ significantly with respect to thyroid gland damage. F1 hybrids, like BSVS mice, respond well to thyroglobulin, exhibiting extensive thyroid lesions, whereas BRVR mice show minimal thyroid damage. H 2 typing of the two strains showed that BSVS mice have a type similar to H 2th, with the H 2D end of H 2d and the H 2K end of H 2s, whereas BRVR mice are H 2k. The cellular response to thyroglobulin appears to be influenced by a specific immune response gene located near the K end of the H 2 complex.

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Autoimmune murine thyroiditis. V. Genetic influence on the disease in BSVS and BRVR mice

Abstract

ASJC Scopus subject areas

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