TY - JOUR
T1 - Autoimmune Movement Disorders
T2 - a Clinical and Laboratory Approach
AU - Honorat, Josephe Archie
AU - McKeon, Andrew
N1 - Publisher Copyright:
© 2017, Springer Science+Business Media New York.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Autoimmune movement disorders are caused by an aberrant immune response to neural self-antigens. These disorders may be paraneoplastic, parainfectious, or (most commonly) idiopathic. The neurological presentations are diverse, and sometimes multifocal. Movement disorders can occur as part of the spectrum with phenotypes including chorea, myoclonus, ataxia, CNS hyperexcitability (including stiff-person syndrome), dystonia, and parkinsonism. Symptoms are subacute in onset and may have a fluctuating course. The best characterized disorders are unified by neural autoantibodies identified in serum or cerebrospinal fluid. The antibody specificity may predict the association with cancer and the response to immunotherapy. In this article, we review autoimmune-mediated movement disorders, associated cancers, diagnosis, and treatment.
AB - Autoimmune movement disorders are caused by an aberrant immune response to neural self-antigens. These disorders may be paraneoplastic, parainfectious, or (most commonly) idiopathic. The neurological presentations are diverse, and sometimes multifocal. Movement disorders can occur as part of the spectrum with phenotypes including chorea, myoclonus, ataxia, CNS hyperexcitability (including stiff-person syndrome), dystonia, and parkinsonism. Symptoms are subacute in onset and may have a fluctuating course. The best characterized disorders are unified by neural autoantibodies identified in serum or cerebrospinal fluid. The antibody specificity may predict the association with cancer and the response to immunotherapy. In this article, we review autoimmune-mediated movement disorders, associated cancers, diagnosis, and treatment.
KW - Autoimmunity
KW - Immunotherapy
KW - Movement disorders
KW - Neuronal autoantibodies
KW - Paraneoplastic
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U2 - 10.1007/s11910-017-0709-2
DO - 10.1007/s11910-017-0709-2
M3 - Review article
C2 - 28120141
AN - SCOPUS:85010908270
SN - 1528-4042
VL - 17
JO - Current neurology and neuroscience reports
JF - Current neurology and neuroscience reports
IS - 1
M1 - 4
ER -