Autoimmune mechanisms in the pathogenesis of paraneoplastic nervous system disease

Kurt A. Jaeckle

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

There is compelling circumstantial evidence that humoral autoimmune response may be involved in the generation of paraneoplastic neurologic syndromes (PNS). However, still it is unproven whether the autoantibody is pathogenic or represents an epiphenomenon to the actual disease process. Paraneoplastic antibodies have been identified in patients with PNS which react with similar antigenic epitopes in tumor and neurons. However, the antigens identified by the paraneoplastic antibodies are primarily intracellular in location, questioning the pathogenetic role of the antibody. The molecular events of antigen processing and presentation, T-cell receptor restriction, polyclonal B-cell proliferation, cellular immunity, and the role of cytokines in mediation of neuronal injury must be further defined in order to elucidate the role of autoimmunity in the pathogenesis of these disorders.

Original languageEnglish (US)
Pages (from-to)82-88
Number of pages7
JournalClinical Neurology and Neurosurgery
Volume97
Issue number1
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Nervous System Paraneoplastic Syndromes
Nervous System Diseases
Antigen Presentation
Autoimmunity
Antibodies
T-Cell Antigen Receptor
Cellular Immunity
Autoantibodies
Epitopes
B-Lymphocytes
Cell Proliferation
Cytokines
Neurons
Antigens
Wounds and Injuries
Neoplasms

Keywords

  • Antibody
  • Autoantibody
  • Autoimmune
  • Paraneoplastic
  • Pathogenesis
  • Tumor antigens

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Neurology

Cite this

Autoimmune mechanisms in the pathogenesis of paraneoplastic nervous system disease. / Jaeckle, Kurt A.

In: Clinical Neurology and Neurosurgery, Vol. 97, No. 1, 1995, p. 82-88.

Research output: Contribution to journalArticle

@article{ef9b6aa709ca414eab79a086fd1c9332,
title = "Autoimmune mechanisms in the pathogenesis of paraneoplastic nervous system disease",
abstract = "There is compelling circumstantial evidence that humoral autoimmune response may be involved in the generation of paraneoplastic neurologic syndromes (PNS). However, still it is unproven whether the autoantibody is pathogenic or represents an epiphenomenon to the actual disease process. Paraneoplastic antibodies have been identified in patients with PNS which react with similar antigenic epitopes in tumor and neurons. However, the antigens identified by the paraneoplastic antibodies are primarily intracellular in location, questioning the pathogenetic role of the antibody. The molecular events of antigen processing and presentation, T-cell receptor restriction, polyclonal B-cell proliferation, cellular immunity, and the role of cytokines in mediation of neuronal injury must be further defined in order to elucidate the role of autoimmunity in the pathogenesis of these disorders.",
keywords = "Antibody, Autoantibody, Autoimmune, Paraneoplastic, Pathogenesis, Tumor antigens",
author = "Jaeckle, {Kurt A.}",
year = "1995",
doi = "10.1016/0303-8467(95)00014-B",
language = "English (US)",
volume = "97",
pages = "82--88",
journal = "Clinical Neurology and Neurosurgery",
issn = "0303-8467",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Autoimmune mechanisms in the pathogenesis of paraneoplastic nervous system disease

AU - Jaeckle, Kurt A.

PY - 1995

Y1 - 1995

N2 - There is compelling circumstantial evidence that humoral autoimmune response may be involved in the generation of paraneoplastic neurologic syndromes (PNS). However, still it is unproven whether the autoantibody is pathogenic or represents an epiphenomenon to the actual disease process. Paraneoplastic antibodies have been identified in patients with PNS which react with similar antigenic epitopes in tumor and neurons. However, the antigens identified by the paraneoplastic antibodies are primarily intracellular in location, questioning the pathogenetic role of the antibody. The molecular events of antigen processing and presentation, T-cell receptor restriction, polyclonal B-cell proliferation, cellular immunity, and the role of cytokines in mediation of neuronal injury must be further defined in order to elucidate the role of autoimmunity in the pathogenesis of these disorders.

AB - There is compelling circumstantial evidence that humoral autoimmune response may be involved in the generation of paraneoplastic neurologic syndromes (PNS). However, still it is unproven whether the autoantibody is pathogenic or represents an epiphenomenon to the actual disease process. Paraneoplastic antibodies have been identified in patients with PNS which react with similar antigenic epitopes in tumor and neurons. However, the antigens identified by the paraneoplastic antibodies are primarily intracellular in location, questioning the pathogenetic role of the antibody. The molecular events of antigen processing and presentation, T-cell receptor restriction, polyclonal B-cell proliferation, cellular immunity, and the role of cytokines in mediation of neuronal injury must be further defined in order to elucidate the role of autoimmunity in the pathogenesis of these disorders.

KW - Antibody

KW - Autoantibody

KW - Autoimmune

KW - Paraneoplastic

KW - Pathogenesis

KW - Tumor antigens

UR - http://www.scopus.com/inward/record.url?scp=0028933384&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028933384&partnerID=8YFLogxK

U2 - 10.1016/0303-8467(95)00014-B

DO - 10.1016/0303-8467(95)00014-B

M3 - Article

VL - 97

SP - 82

EP - 88

JO - Clinical Neurology and Neurosurgery

JF - Clinical Neurology and Neurosurgery

SN - 0303-8467

IS - 1

ER -