TY - JOUR
T1 - Autoimmune hemolytic anemia in a patient with autosomal dominant chronic mucocutaneous candidiasis
AU - Steensma, David P.
AU - Tefferi, Ayalew
AU - Weiler, Catherine R.
PY - 2000
Y1 - 2000
N2 - Chronic mucocutaneous candidiasis is a heterogeneous immunodeficiency syndrome characterized by recurrent candidal infections of the skin, nails, and mucous membranes. The syndrome can be associated with autoimmune conditions, especially endocrine disorders. Typically, inheritance is autosomal recessive, and abnormal T-cell-mediated immunity is thought to be the underlying deficit. We describe a 27-year-old man with chronic mucocutaneous candidiasis inherited in an autosomal dominant fashion, in whom both lymphocyte blastogenesis and delayed-type skin reactivity to Candida antigens were normal. Notable features of the case include autoimmune hemolytic anemia, probable hypoparathyroidism, and hypogonadal hypogonadism.
AB - Chronic mucocutaneous candidiasis is a heterogeneous immunodeficiency syndrome characterized by recurrent candidal infections of the skin, nails, and mucous membranes. The syndrome can be associated with autoimmune conditions, especially endocrine disorders. Typically, inheritance is autosomal recessive, and abnormal T-cell-mediated immunity is thought to be the underlying deficit. We describe a 27-year-old man with chronic mucocutaneous candidiasis inherited in an autosomal dominant fashion, in whom both lymphocyte blastogenesis and delayed-type skin reactivity to Candida antigens were normal. Notable features of the case include autoimmune hemolytic anemia, probable hypoparathyroidism, and hypogonadal hypogonadism.
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U2 - 10.4065/75.8.853
DO - 10.4065/75.8.853
M3 - Article
C2 - 10943243
AN - SCOPUS:0033888472
SN - 0025-6196
VL - 75
SP - 853
EP - 855
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 8
ER -