Autoimmune form of myasthenia gravis in a juvenile Yorkshire Terrier x Jack Russell Terrier hybrid contrasted with congenital (non-autoimmune) myasthenia gravis of the Jack Russell

A. C. Palmer, Vanda A Lennon, C. Beadle, J. V. Goodyear

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A case of juvenile onset myasthenia gravis is described in a Yorkshire Terrier x Jack Russell bitch in which there were serum autoantibodies to acetylcholine receptors and reduction in the muscle's content of acetylcholine receptors. Approximately 25% of the receptors remaining were complexed with antibody. After 8 months of treatment with the anticholesterase pyridostigmin, the animal made a complete recovery and the serum level of antibody decreased. The condition of this dog in many respects resembled acquired myasthenia gravis of adult onset and is contrasted with the seven cases of congenital myasthenia gravis which we have studied in the Jack Russell Terrier. In the congenital form of myasthenia gravis, reduction of acetylcholine receptors in muscle is found without any demonstratble autoantibodies to acetylcholine receptors, either in serum or muscle.

Original languageEnglish (US)
Pages (from-to)359-364
Number of pages6
JournalJournal of Small Animal Practice
Volume21
Issue number6
StatePublished - 1980

Fingerprint

cholinergic receptors
terriers
Myasthenia Gravis
Cholinergic Receptors
Congenital Myasthenic Syndromes
autoantibodies
Muscles
Autoantibodies
muscles
Serum
antibodies
Antibodies
bitches
Dogs
receptors
Yorkshire Terrier
dogs
animals

ASJC Scopus subject areas

  • veterinary(all)

Cite this

@article{169cd52dec334eb18720088e11f0a51d,
title = "Autoimmune form of myasthenia gravis in a juvenile Yorkshire Terrier x Jack Russell Terrier hybrid contrasted with congenital (non-autoimmune) myasthenia gravis of the Jack Russell",
abstract = "A case of juvenile onset myasthenia gravis is described in a Yorkshire Terrier x Jack Russell bitch in which there were serum autoantibodies to acetylcholine receptors and reduction in the muscle's content of acetylcholine receptors. Approximately 25{\%} of the receptors remaining were complexed with antibody. After 8 months of treatment with the anticholesterase pyridostigmin, the animal made a complete recovery and the serum level of antibody decreased. The condition of this dog in many respects resembled acquired myasthenia gravis of adult onset and is contrasted with the seven cases of congenital myasthenia gravis which we have studied in the Jack Russell Terrier. In the congenital form of myasthenia gravis, reduction of acetylcholine receptors in muscle is found without any demonstratble autoantibodies to acetylcholine receptors, either in serum or muscle.",
author = "Palmer, {A. C.} and Lennon, {Vanda A} and C. Beadle and Goodyear, {J. V.}",
year = "1980",
language = "English (US)",
volume = "21",
pages = "359--364",
journal = "Journal of Small Animal Practice",
issn = "0022-4510",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Autoimmune form of myasthenia gravis in a juvenile Yorkshire Terrier x Jack Russell Terrier hybrid contrasted with congenital (non-autoimmune) myasthenia gravis of the Jack Russell

AU - Palmer, A. C.

AU - Lennon, Vanda A

AU - Beadle, C.

AU - Goodyear, J. V.

PY - 1980

Y1 - 1980

N2 - A case of juvenile onset myasthenia gravis is described in a Yorkshire Terrier x Jack Russell bitch in which there were serum autoantibodies to acetylcholine receptors and reduction in the muscle's content of acetylcholine receptors. Approximately 25% of the receptors remaining were complexed with antibody. After 8 months of treatment with the anticholesterase pyridostigmin, the animal made a complete recovery and the serum level of antibody decreased. The condition of this dog in many respects resembled acquired myasthenia gravis of adult onset and is contrasted with the seven cases of congenital myasthenia gravis which we have studied in the Jack Russell Terrier. In the congenital form of myasthenia gravis, reduction of acetylcholine receptors in muscle is found without any demonstratble autoantibodies to acetylcholine receptors, either in serum or muscle.

AB - A case of juvenile onset myasthenia gravis is described in a Yorkshire Terrier x Jack Russell bitch in which there were serum autoantibodies to acetylcholine receptors and reduction in the muscle's content of acetylcholine receptors. Approximately 25% of the receptors remaining were complexed with antibody. After 8 months of treatment with the anticholesterase pyridostigmin, the animal made a complete recovery and the serum level of antibody decreased. The condition of this dog in many respects resembled acquired myasthenia gravis of adult onset and is contrasted with the seven cases of congenital myasthenia gravis which we have studied in the Jack Russell Terrier. In the congenital form of myasthenia gravis, reduction of acetylcholine receptors in muscle is found without any demonstratble autoantibodies to acetylcholine receptors, either in serum or muscle.

UR - http://www.scopus.com/inward/record.url?scp=0019308983&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019308983&partnerID=8YFLogxK

M3 - Article

C2 - 7431884

AN - SCOPUS:0019308983

VL - 21

SP - 359

EP - 364

JO - Journal of Small Animal Practice

JF - Journal of Small Animal Practice

SN - 0022-4510

IS - 6

ER -