Autoimmune form of myasthenia gravis in a juvenile Yorkshire Terrier x Jack Russell Terrier hybrid contrasted with congenital (non‐autoimmune) myasthenia gravis of the Jack Russell

A. C. PALMER, VANDA A. LENNON, CATHERINE BEADLE, J. V. GOODYEAR

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

A case of juvenile onset myasthenia gravis is described in a Yorkshire Terrier x Jack Russell bitch in which there were serum autoantibodies to acetylcholine receptors and reduction in the muscle's content of acetylcholine receptors. Approximately 25% of the receptors remaining were complexed with antibody. After 8 months of treatment with the anticholinesterase pyridostigmin, the animal made a complete recovery and the serum level of antibody decreased. The condition of this dog in many respects resembled acquired myasthenia gravis of adult onset and is contrasted with the seven cases of congenital myasthenia gravis which we have studied in the Jack Russell Terrier. In the congenital form of myasthenia gravis, reduction of acetylcholine receptors in muscle is found without any demonstrable autoantibodies to acetylcholine receptors, either in serum or muscle.

Original languageEnglish (US)
Pages (from-to)359-364
Number of pages6
JournalJournal of Small Animal Practice
Volume21
Issue number6
DOIs
StatePublished - Jun 1980

ASJC Scopus subject areas

  • Small Animals

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