Autoimmune epilepsy

Jeffrey Britton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

12 Citations (Scopus)

Abstract

Seizures are a common manifestation of autoimmune limbic encephalitis and multifocal paraneoplastic disorders. Accumulating evidence supports an autoimmune basis for seizures in the absence of syndromic manifestations of encephalitis. The autoimmune epilepsies are immunologically mediated disorders in which recurrent seizures are a primary and persistent clinical feature. When other etiologies have been excluded, an autoimmune etiology is suggested in a patient with epilepsy upon detection of neural autoantibodies and/or the presence of inflammatory changes on cerebrospinal fluid (CSF) or magnetic resonance imaging. In such patients, immunotherapy may be highly effective, depending on the particular autoimmune epilepsy syndrome present. In this chapter, several autoimmune epilepsy syndromes are discussed. First, epilepsies secondary to other primary autoimmune disorders will be discussed, and then those associated with antibodies that are likely to be pathogenic, such as voltage-gated potassium channel-complex and N-methyl-. d-aspartate receptor, gamma-aminobutyric acid A and B receptor antibodies. For each syndrome, the typical clinical, imaging, electroencephaloram, CSF, and serologic features, and pathophysiology and treatment are described. Finally, suggested guidelines for the recognition, evaluation, and treatment of autoimmune epilepsy syndromes are provided.

Original languageEnglish (US)
Title of host publicationAutoimmune Neurology, 2016
PublisherElsevier
Pages219-245
Number of pages27
Volume133
ISBN (Print)9780444634320
DOIs
StatePublished - 2016

Publication series

NameHandbook of Clinical Neurology
Volume133
ISSN (Print)00729752
ISSN (Electronic)22124152

Fingerprint

Epilepsy
Cerebrospinal Fluid
Seizures
Voltage-Gated Potassium Channels
Absence Epilepsy
Antibodies
Encephalitis
Autoantibodies
Immunotherapy
gamma-Aminobutyric Acid
Magnetic Resonance Imaging
Guidelines
Therapeutics

Keywords

  • Autoimmune encephalitis
  • Autoimmune epilepsy
  • Limbic encephalitis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Britton, J. (2016). Autoimmune epilepsy. In Autoimmune Neurology, 2016 (Vol. 133, pp. 219-245). (Handbook of Clinical Neurology; Vol. 133). Elsevier. https://doi.org/10.1016/B978-0-444-63432-0.00013-X

Autoimmune epilepsy. / Britton, Jeffrey.

Autoimmune Neurology, 2016. Vol. 133 Elsevier, 2016. p. 219-245 (Handbook of Clinical Neurology; Vol. 133).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Britton, J 2016, Autoimmune epilepsy. in Autoimmune Neurology, 2016. vol. 133, Handbook of Clinical Neurology, vol. 133, Elsevier, pp. 219-245. https://doi.org/10.1016/B978-0-444-63432-0.00013-X
Britton J. Autoimmune epilepsy. In Autoimmune Neurology, 2016. Vol. 133. Elsevier. 2016. p. 219-245. (Handbook of Clinical Neurology). https://doi.org/10.1016/B978-0-444-63432-0.00013-X
Britton, Jeffrey. / Autoimmune epilepsy. Autoimmune Neurology, 2016. Vol. 133 Elsevier, 2016. pp. 219-245 (Handbook of Clinical Neurology).
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