Autoimmune enteropathy: A review and update of clinical management

Nicole M. Gentile, Joseph A Murray, Darrell S. Pardi

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Autoimmune enteropathy (AIE) is a rare condition characterized by intractable diarrhea, histologic changes on small intestinal biopsy, and failed response to dietary manipulation that also may present with extraintestinal manifestations. In many patients, immunosuppressive therapies are necessary. Although AIE is more common in infants, adult involvement has also been documented.Much of what is known about AIE has been gathered from case reports and small case series; therefore, more research in this evolving field is needed. IPEX (immunodysregulation polyendocrinopathy enteropathy X-linked syndrome) and APECED (autoimmune phenomena, polyendocrinopathy, candidiasis, and ectodermal dystrophy) are systemic forms of AIE.

Original languageEnglish (US)
Pages (from-to)380-385
Number of pages6
JournalCurrent Gastroenterology Reports
Volume14
Issue number5
DOIs
StatePublished - Oct 2012

Fingerprint

Autoimmune Polyendocrinopathies
Immunosuppressive Agents
Diarrhea
Biopsy
Autoimmune enteropathy
Research
Therapeutics
Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome
Type 1 Autoimmune polyendocrinopathy syndrome

Keywords

  • Autoimmune enteropathy (AIE)
  • Autoimmune phenomena polyendocrinopathy candidiasis and ectodermal dystrophy (APECED)
  • Immunodysregulation polyendocrinopathy enteropathy X-linked syndrome (IPEX)
  • Intractable diarrhea

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Autoimmune enteropathy : A review and update of clinical management. / Gentile, Nicole M.; Murray, Joseph A; Pardi, Darrell S.

In: Current Gastroenterology Reports, Vol. 14, No. 5, 10.2012, p. 380-385.

Research output: Contribution to journalArticle

Gentile, Nicole M. ; Murray, Joseph A ; Pardi, Darrell S. / Autoimmune enteropathy : A review and update of clinical management. In: Current Gastroenterology Reports. 2012 ; Vol. 14, No. 5. pp. 380-385.
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