Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: A pooled analysis within the InterLymph Consortium

Karin Ekström Smedby, Claire M. Vajdic, Michael Falster, Eric A. Engels, Otoniel Martinez-Maza, Jennifer Turner, Henrik Hjalgrim, Paolo Vineis, Adele Seniori Costantini, Paige M. Bracci, Elizabeth A. Holly, Eleanor Willett, John J. Spinelli, Carlo La Vecchia, Tongzhang Zheng, Nikolaus Becker, Silvia De Sanjosé, Brian C H Chiu, Luigino Dal Maso, Pierluigi CoccoMarc Maynadie, Lenka Foretova, Anthony Staines, Paul Brennan, Scott Davis, Richard Severson, James R Cerhan, Elizabeth C. Breen, Brenda Birmann, Andrew E. Grulich, Wendy Cozen

Research output: Contribution to journalArticle

362 Citations (Scopus)

Abstract

Some autoimmune disorders are increasingly recognized as risk factors for non-Hodgkin lymphoma (NHL) overall, but large-scale systematic assessments of risk of NHL subtypes are lacking. We performed a pooled analysis of self-reported autoimmune conditions and risk of NHL and subtypes, including 29 423 participants in 12 case-control studies. We computed pooled odds ratios (OR) and 95% confidence intervals (CI) in a joint fixed-effects model. Sjögren syndrome was associated with a 6.5-fold increased risk of NHL, a 1000-fold increased risk of parotid gland marginal zone lymphoma (OR = 996; 95% CI, 216-4596), and with diffuse large B-cell and follicular lymphomas. Systemic lupus erythematosus was associated with a 2.7-fold increased risk of NHL and with diffuse large B-cell and marginal zone lymphomas. Hemolytic anemia was associated with diffuse large B-cell NHL. T-cell NHL risk was increased for patients with celiac disease and psoriasis. Results for rheumatoid arthritis were heterogeneous between studies. Inflammatory bowel disorders, type 1 diabetes, sarcoidosis, pernicious anemia, and multiple sclerosis were not associated with risk of NHL or subtypes. Thus, specific autoimmune disorders are associated with NHL risk beyond the development of rare NHL subtypes in affected organs. The pattern of associations with NHL subtypes may harbor clues to lym-phomagenesis.

Original languageEnglish (US)
Pages (from-to)4029-4038
Number of pages10
JournalBlood
Volume111
Issue number8
DOIs
StatePublished - Apr 15 2008

Fingerprint

Non-Hodgkin's Lymphoma
Cells
Odds Ratio
T-cells
Confidence Intervals
Pernicious Anemia
Medical problems
Ports and harbors
Marginal Zone B-Cell Lymphoma
Follicular Lymphoma
Lymphoma, Large B-Cell, Diffuse
T-Cell Lymphoma
Hemolytic Anemia
Parotid Gland
Celiac Disease
B-Cell Lymphoma
Sarcoidosis
Type 1 Diabetes Mellitus
Psoriasis
Systemic Lupus Erythematosus

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

Smedby, K. E., Vajdic, C. M., Falster, M., Engels, E. A., Martinez-Maza, O., Turner, J., ... Cozen, W. (2008). Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: A pooled analysis within the InterLymph Consortium. Blood, 111(8), 4029-4038. https://doi.org/10.1182/blood-2007-10-119974

Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes : A pooled analysis within the InterLymph Consortium. / Smedby, Karin Ekström; Vajdic, Claire M.; Falster, Michael; Engels, Eric A.; Martinez-Maza, Otoniel; Turner, Jennifer; Hjalgrim, Henrik; Vineis, Paolo; Costantini, Adele Seniori; Bracci, Paige M.; Holly, Elizabeth A.; Willett, Eleanor; Spinelli, John J.; Vecchia, Carlo La; Zheng, Tongzhang; Becker, Nikolaus; De Sanjosé, Silvia; Chiu, Brian C H; Maso, Luigino Dal; Cocco, Pierluigi; Maynadie, Marc; Foretova, Lenka; Staines, Anthony; Brennan, Paul; Davis, Scott; Severson, Richard; Cerhan, James R; Breen, Elizabeth C.; Birmann, Brenda; Grulich, Andrew E.; Cozen, Wendy.

In: Blood, Vol. 111, No. 8, 15.04.2008, p. 4029-4038.

Research output: Contribution to journalArticle

Smedby, KE, Vajdic, CM, Falster, M, Engels, EA, Martinez-Maza, O, Turner, J, Hjalgrim, H, Vineis, P, Costantini, AS, Bracci, PM, Holly, EA, Willett, E, Spinelli, JJ, Vecchia, CL, Zheng, T, Becker, N, De Sanjosé, S, Chiu, BCH, Maso, LD, Cocco, P, Maynadie, M, Foretova, L, Staines, A, Brennan, P, Davis, S, Severson, R, Cerhan, JR, Breen, EC, Birmann, B, Grulich, AE & Cozen, W 2008, 'Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: A pooled analysis within the InterLymph Consortium', Blood, vol. 111, no. 8, pp. 4029-4038. https://doi.org/10.1182/blood-2007-10-119974
Smedby KE, Vajdic CM, Falster M, Engels EA, Martinez-Maza O, Turner J et al. Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: A pooled analysis within the InterLymph Consortium. Blood. 2008 Apr 15;111(8):4029-4038. https://doi.org/10.1182/blood-2007-10-119974
Smedby, Karin Ekström ; Vajdic, Claire M. ; Falster, Michael ; Engels, Eric A. ; Martinez-Maza, Otoniel ; Turner, Jennifer ; Hjalgrim, Henrik ; Vineis, Paolo ; Costantini, Adele Seniori ; Bracci, Paige M. ; Holly, Elizabeth A. ; Willett, Eleanor ; Spinelli, John J. ; Vecchia, Carlo La ; Zheng, Tongzhang ; Becker, Nikolaus ; De Sanjosé, Silvia ; Chiu, Brian C H ; Maso, Luigino Dal ; Cocco, Pierluigi ; Maynadie, Marc ; Foretova, Lenka ; Staines, Anthony ; Brennan, Paul ; Davis, Scott ; Severson, Richard ; Cerhan, James R ; Breen, Elizabeth C. ; Birmann, Brenda ; Grulich, Andrew E. ; Cozen, Wendy. / Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes : A pooled analysis within the InterLymph Consortium. In: Blood. 2008 ; Vol. 111, No. 8. pp. 4029-4038.
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abstract = "Some autoimmune disorders are increasingly recognized as risk factors for non-Hodgkin lymphoma (NHL) overall, but large-scale systematic assessments of risk of NHL subtypes are lacking. We performed a pooled analysis of self-reported autoimmune conditions and risk of NHL and subtypes, including 29 423 participants in 12 case-control studies. We computed pooled odds ratios (OR) and 95{\%} confidence intervals (CI) in a joint fixed-effects model. Sj{\"o}gren syndrome was associated with a 6.5-fold increased risk of NHL, a 1000-fold increased risk of parotid gland marginal zone lymphoma (OR = 996; 95{\%} CI, 216-4596), and with diffuse large B-cell and follicular lymphomas. Systemic lupus erythematosus was associated with a 2.7-fold increased risk of NHL and with diffuse large B-cell and marginal zone lymphomas. Hemolytic anemia was associated with diffuse large B-cell NHL. T-cell NHL risk was increased for patients with celiac disease and psoriasis. Results for rheumatoid arthritis were heterogeneous between studies. Inflammatory bowel disorders, type 1 diabetes, sarcoidosis, pernicious anemia, and multiple sclerosis were not associated with risk of NHL or subtypes. Thus, specific autoimmune disorders are associated with NHL risk beyond the development of rare NHL subtypes in affected organs. The pattern of associations with NHL subtypes may harbor clues to lym-phomagenesis.",
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