Autoimmune cytopenia in chronic lymphocytic leukemia/small lymphocytic lymphoma: Changes in clinical presentation and prognosis

Clive S. Zent, Wei D Ding, Megan S. Reinalda, Susan M. Schwager, James Hoyer, Deborah A. Bowen, Diane F Jelinek, Renee C. Tschumper, Timothy G. Call, Tait D. Shanafelt, Neil Elliot Kay, Susan L Slager

Research output: Contribution to journalArticle

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Abstract

Improved medical care could have altered the clinical presentation and survival of patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) complicated by autoimmune disease cytopenia (AID cytopenia). We reviewed the clinical characteristics, treatment, and outcome of AID cytopenia that was diagnosed in 75 (4.3%) of 1750 patients with CLL seen at a single institution over 10 years. When compared with the historical reported data, our study shows a lower rate of autoimmune hemolytic anemia (2.3%), and similar rates of immune thrombocytopenia (2.0%), and pure red blood cell aplasia (0.5%). AID cytopenia occurred at all stages of CLL, responded well to treatment, did not alter overall survival, and contributed to death in only 6 (12%) patients. We propose that more sensitive and accurate diagnostic methods for CLL have decreased the perceived prevalence of AID cytopenia and that improvements in management could have increased the survival of these patients.

Original languageEnglish (US)
Pages (from-to)1261-1268
Number of pages8
JournalLeukemia and Lymphoma
Volume50
Issue number8
DOIs
StatePublished - 2009

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B-Cell Chronic Lymphocytic Leukemia
Autoimmune Diseases
Survival
Pure Red-Cell Aplasia
Autoimmune Hemolytic Anemia
Idiopathic Thrombocytopenic Purpura
Erythrocytes
Therapeutics

Keywords

  • autoimmune hemolytic anemia
  • Chronic lymphocytic leukemia
  • cytopenia
  • immune thrombocytopenia
  • pure red blood cell aplasia

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research
  • Medicine(all)

Cite this

Autoimmune cytopenia in chronic lymphocytic leukemia/small lymphocytic lymphoma : Changes in clinical presentation and prognosis. / Zent, Clive S.; Ding, Wei D; Reinalda, Megan S.; Schwager, Susan M.; Hoyer, James; Bowen, Deborah A.; Jelinek, Diane F; Tschumper, Renee C.; Call, Timothy G.; Shanafelt, Tait D.; Kay, Neil Elliot; Slager, Susan L.

In: Leukemia and Lymphoma, Vol. 50, No. 8, 2009, p. 1261-1268.

Research output: Contribution to journalArticle

Zent, Clive S. ; Ding, Wei D ; Reinalda, Megan S. ; Schwager, Susan M. ; Hoyer, James ; Bowen, Deborah A. ; Jelinek, Diane F ; Tschumper, Renee C. ; Call, Timothy G. ; Shanafelt, Tait D. ; Kay, Neil Elliot ; Slager, Susan L. / Autoimmune cytopenia in chronic lymphocytic leukemia/small lymphocytic lymphoma : Changes in clinical presentation and prognosis. In: Leukemia and Lymphoma. 2009 ; Vol. 50, No. 8. pp. 1261-1268.
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