TY - JOUR
T1 - Autoimmune and Paraneoplastic Myelopathies
AU - Zalewski, Nicholas L.
AU - Flanagan, Eoin P.
N1 - Publisher Copyright:
Copyright © 2018 by Thieme Medical Publishers, Inc.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Prompt recognition of an inflammatory myelopathy is critical, as a specific diagnosis and management plan allows for optimal patient outcomes. Many treatment options are now available for autoimmune and paraneoplastic myelopathies, but specific management strategies and expected prognosis vary widely depending on the underlying etiology. An understanding of the relevant clinical details, imaging findings, and other diagnostic information that can help achieve a specific myelopathy diagnosis and treatment plan is essential for all neurologists, given the variety of contexts in which myelopathies are encountered. We provide an outline of the diagnostic evaluation and treatment of various inflammatory myelopathies seen in autoimmune and paraneoplastic diseases, including multiple sclerosis, aquaporin-4 immunoglobulin G (IgG) seropositive neuromyelitis optica spectrum disorder, sarcoidosis, myelin oligodendrocyte glycoprotein IgG associated disease, and other rare inflammatory myelopathies; we also highlight common mimickers of inflammatory myelopathies.
AB - Prompt recognition of an inflammatory myelopathy is critical, as a specific diagnosis and management plan allows for optimal patient outcomes. Many treatment options are now available for autoimmune and paraneoplastic myelopathies, but specific management strategies and expected prognosis vary widely depending on the underlying etiology. An understanding of the relevant clinical details, imaging findings, and other diagnostic information that can help achieve a specific myelopathy diagnosis and treatment plan is essential for all neurologists, given the variety of contexts in which myelopathies are encountered. We provide an outline of the diagnostic evaluation and treatment of various inflammatory myelopathies seen in autoimmune and paraneoplastic diseases, including multiple sclerosis, aquaporin-4 immunoglobulin G (IgG) seropositive neuromyelitis optica spectrum disorder, sarcoidosis, myelin oligodendrocyte glycoprotein IgG associated disease, and other rare inflammatory myelopathies; we also highlight common mimickers of inflammatory myelopathies.
KW - neuromyelitis optica
KW - spinal cord
KW - transverse myelitis
UR - http://www.scopus.com/inward/record.url?scp=85050205925&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85050205925&partnerID=8YFLogxK
U2 - 10.1055/s-0038-1660856
DO - 10.1055/s-0038-1660856
M3 - Article
C2 - 30011409
AN - SCOPUS:85050205925
SN - 0271-8235
VL - 38
SP - 278
EP - 289
JO - Seminars in Neurology
JF - Seminars in Neurology
IS - 3
ER -