TY - JOUR
T1 - Autoantibodies with enzymatic properties in human autoimmune diseases
AU - Wootla, Bharath
AU - Lacroix-Desmazes, Sébastien
AU - Warrington, Arthur E.
AU - Bieber, Allan J.
AU - Kaveri, Srini V.
AU - Rodriguez, Moses
N1 - Funding Information:
(SLD and SVK) This work was supported by INSERM , CNRS , the Indo-French Center for Promotion of Advanced Research (CEFIPRA) , Agence Nationale de la Recherche ( ANR-05-MRAR-012 , ANR-09-GENO-028 ) and from Japan Sciences and Technology Agency (JST, Tokyo, Japan). BW was the recipient of a fellowship from Laboratoire Français de Fractionnement et des Biotechnologies (LFB) while in France and is currently funded by a fellowship from the Mayo-Applebaum funds. (MR, AW, and AB) This work was also supported by grants from the National Institutes of Health ( R01s GM092993 , NS024180 , NS032129 , NS048357 , R21 NS073684 ), the National Multiple Sclerosis Society ( CA1060A11 ), the Applebaum Foundation , the Hilton Foundation , the Minnesota Partnership Award for Biotechnology and Medical Genomics .
PY - 2011/9
Y1 - 2011/9
N2 - Immunoglobulins (Ig) or antibodies are heavy plasma proteins, with sugar chains added to amino acid residues by N-linked glycosylation and occasionally by O-linked glycosylation. The versatility of antibodies is demonstrated by the various functions that they mediate such as neutralization, agglutination, fixation with activation of complement and activation of effector cells. In addition to this plethora of functions, some antibodies express enzymatic activity. Antibodies endowed with enzymatic properties have been described in human autoimmune manifestations in a variety of disorders such as autoimmune thyroiditis, systemic erythematosus (SLE), scleroderma, rheumatoid arthritis (RA), multiple sclerosis (MS) and acquired hemophilia (AH). Antibodies isolated from these conditions were able to specifically hydrolyze thyroglobulin, DNA, RNA, myelin basic protein (MBP), and factor VIII (FVIII) or factor IX (FIX), respectively. The therapeutic relevance of these findings is discussed.
AB - Immunoglobulins (Ig) or antibodies are heavy plasma proteins, with sugar chains added to amino acid residues by N-linked glycosylation and occasionally by O-linked glycosylation. The versatility of antibodies is demonstrated by the various functions that they mediate such as neutralization, agglutination, fixation with activation of complement and activation of effector cells. In addition to this plethora of functions, some antibodies express enzymatic activity. Antibodies endowed with enzymatic properties have been described in human autoimmune manifestations in a variety of disorders such as autoimmune thyroiditis, systemic erythematosus (SLE), scleroderma, rheumatoid arthritis (RA), multiple sclerosis (MS) and acquired hemophilia (AH). Antibodies isolated from these conditions were able to specifically hydrolyze thyroglobulin, DNA, RNA, myelin basic protein (MBP), and factor VIII (FVIII) or factor IX (FIX), respectively. The therapeutic relevance of these findings is discussed.
KW - Abzymes
KW - Autoantibodies
KW - Autoimmunity
KW - Catalytic antibodies
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U2 - 10.1016/j.jaut.2011.05.007
DO - 10.1016/j.jaut.2011.05.007
M3 - Review article
C2 - 21624820
AN - SCOPUS:80052650654
SN - 0896-8411
VL - 37
SP - 144
EP - 150
JO - Journal of Autoimmunity
JF - Journal of Autoimmunity
IS - 2
ER -