@article{13c5d180dcbd454b885b4165167bd86b,
title = "Autoantibodies in juvenile arthritis",
abstract = "Sera from 104 children with JA with different onset-types of disease were evaluated for 19S IgM RF by the LFT, hidden 19S IgM RF by the hemolytic assay, ANA by HEp-2 cell substrate, and levels of IC by the C1qSPA. Their relationship to active disease was determined. Classical 19S IgM RF were detected by the LFT in only seven patients. All were late-onset polyarticular females. Hidden 19S IgM RF were detected by the hemolytic assay in the separated IgM-containing fraction in 55 patients of all onset-types. Clinical activity correlated with the presence of hidden 19S IgM RF in 82% of cases. ANA, using the HEp-2 cell substrate, were found in 61 patients, the majority showing a speckled, immunofluorescent pattern. ANA were noted in all RF positive patients and in nine of 10 patients with iridocyclitis. IC were found in 39 patients, and correlation with clinical activity occurred in 54% of cases.",
author = "Moore, {Terry L.} and Osborn, {Thomas G.} and Weiss, {Terry D.} and Sheridan, {P. Wayne} and Eisenwinter, {Ronald K.} and Miller, {Anne V.} and Dorner, {Robert W.} and Jack Zuckner",
note = "Funding Information: From the Division of Rheumatology, Departments of Internal Medicine and Pediatrics-Adolescent Medicine, St. Louis University School of Medicine, and Cardinal Glennon Memorial Hospital for Children, St. Louis, MO. Supported in part by grants from the USPHS, RR05388, AM01036 (a Research Career Development Award to Dr. Moore), the National Easter Seal Society, and the JRA Parents{\textquoteright} Group, Inc. of St. Louis, MO. Terry L. Moore, M.D.: Associate Professor of Internal Medicine and Pediatrics-Adolescent Medicine, Director, Division of Pediatric Rheumatology, Cardinal Glennon Memorial Hospitalfor Children; Thomas G. Osborn, M.D.: Assistant Professor of Internal Medicine; Terry D. Weiss, M.D.: Associate Clinical Professor of Internal Medicine; P. Wayne Sheridan, M.S.: Research Associate, Department of Internal Medicine: Ronald K. Eisenwinter. A.B.: Research Assistant, Departmento f Internal Medicine: Anne V. Miller, M.D.: Assistant Professor of Internal Medicine; Robert W. Dorner, Ph.D.: Associate Professor of Internal Medicine and Biochemistry; Jack Zuckner, M.D.: Clinical Professor of Internal Medicine, Director, Division of Rheumatology, St. Louis University School of Medicine, St. Louis, MO. Address reprint requests to Terry L. Moore, M.D., St. Louis University School of Medicine, Division of Rheumatology, Room R215 Doisy Hall, 1402 South Grand Boulevard, St. Louis, MO 63104. 0 I984 by Grune & Stratton, Inc. 0049-0172/84/I 304-0003$5.00/0",
year = "1984",
month = may,
doi = "10.1016/0049-0172(84)90013-1",
language = "English (US)",
volume = "13",
pages = "329--336",
journal = "Seminars in Arthritis and Rheumatism",
issn = "0049-0172",
publisher = "W.B. Saunders Ltd",
number = "4",
}