Author reply: the master-question: meta-analyses and stopped-early randomized trials-a problem?

Dirk Bassler; Ignacio Ferreira-Gonzalez; Matthias Briel; Deborah J. Cook; P. J. Devereaux; Diane Heels-Ansdell; Haresh Kirpalani; Maureen O. Meade; Victor M. Montori; Anna Rozenberg; Holger J. Schünemann; Gordon H. Guyatt

doi:10.1016/j.jclinepi.2007.08.006

Author reply: the master-question: meta-analyses and stopped-early randomized trials-a problem?

Dirk Bassler, Ignacio Ferreira-Gonzalez, Matthias Briel, Deborah J. Cook, P. J. Devereaux, Diane Heels-Ansdell, Haresh Kirpalani, Maureen O. Meade, Victor M. Montori, Anna Rozenberg, Holger J. Schünemann, Gordon H. Guyatt

Research output: Contribution to journal › Letter › peer-review

Original language	English (US)
Pages (from-to)	96-98
Number of pages	3
Journal	Journal of Clinical Epidemiology
Volume	61
Issue number	1
DOIs	https://doi.org/10.1016/j.jclinepi.2007.08.006
State	Published - Jan 2008

ASJC Scopus subject areas

Epidemiology

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10.1016/j.jclinepi.2007.08.006

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Bassler, D., Ferreira-Gonzalez, I., Briel, M., Cook, D. J., Devereaux, P. J., Heels-Ansdell, D., Kirpalani, H., Meade, M. O., Montori, V. M., Rozenberg, A., Schünemann, H. J., & H. Guyatt, G. (2008). Author reply: the master-question: meta-analyses and stopped-early randomized trials-a problem? Journal of Clinical Epidemiology, 61(1), 96-98. https://doi.org/10.1016/j.jclinepi.2007.08.006

Bassler, D, Ferreira-Gonzalez, I, Briel, M, Cook, DJ, Devereaux, PJ, Heels-Ansdell, D, Kirpalani, H, Meade, MO, Montori, VM, Rozenberg, A, Schünemann, HJ & H. Guyatt, G 2008, 'Author reply: the master-question: meta-analyses and stopped-early randomized trials-a problem?', Journal of Clinical Epidemiology, vol. 61, no. 1, pp. 96-98. https://doi.org/10.1016/j.jclinepi.2007.08.006

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title = "Author reply: the master-question: meta-analyses and stopped-early randomized trials-a problem?",

author = "Dirk Bassler and Ignacio Ferreira-Gonzalez and Matthias Briel and Cook, {Deborah J.} and Devereaux, {P. J.} and Diane Heels-Ansdell and Haresh Kirpalani and Meade, {Maureen O.} and Montori, {Victor M.} and Anna Rozenberg and Sch{\"u}nemann, {Holger J.} and {H. Guyatt}, Gordon",

note = "Funding Information: We thank Dr. Goodman for joining the debate on RCTs stopped early for benefit, which helps to raise awareness about this important issue. Dr. Goodman's skepticism about our conclusion highlights the need for further empirical research. We have launched the Study of Policy of Interim Truncation—2 (STOPIT-2), an international methodological study funded by the British Medical Research Council [10] . STOPIT-2 seeks to determine the magnitude and determinants of bias that early stopping introduces by comparing treatment effects of studies stopped early for benefit with a pooled estimate of RCTs addressing the same question as the stopped-early studies [10] . Hopefully, the results of STOPIT-2 will, in the future, guide the interpretation of stopped-early trials, and will inform clinicians, investigators, institutional review boards, funding agencies, and DMCs about the appropriate use of stopping rules in clinical trials.",

year = "2008",

month = jan,

doi = "10.1016/j.jclinepi.2007.08.006",

language = "English (US)",

volume = "61",

pages = "96--98",

journal = "Journal of Clinical Epidemiology",

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T2 - the master-question: meta-analyses and stopped-early randomized trials-a problem?

AU - Bassler, Dirk

AU - Ferreira-Gonzalez, Ignacio

AU - Briel, Matthias

AU - Cook, Deborah J.

AU - Devereaux, P. J.

AU - Heels-Ansdell, Diane

AU - Kirpalani, Haresh

AU - Meade, Maureen O.

AU - Montori, Victor M.

AU - Rozenberg, Anna

AU - Schünemann, Holger J.

AU - H. Guyatt, Gordon

N1 - Funding Information: We thank Dr. Goodman for joining the debate on RCTs stopped early for benefit, which helps to raise awareness about this important issue. Dr. Goodman's skepticism about our conclusion highlights the need for further empirical research. We have launched the Study of Policy of Interim Truncation—2 (STOPIT-2), an international methodological study funded by the British Medical Research Council [10] . STOPIT-2 seeks to determine the magnitude and determinants of bias that early stopping introduces by comparing treatment effects of studies stopped early for benefit with a pooled estimate of RCTs addressing the same question as the stopped-early studies [10] . Hopefully, the results of STOPIT-2 will, in the future, guide the interpretation of stopped-early trials, and will inform clinicians, investigators, institutional review boards, funding agencies, and DMCs about the appropriate use of stopping rules in clinical trials.

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JO - Journal of Clinical Epidemiology

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Author reply: the master-question: meta-analyses and stopped-early randomized trials-a problem?

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