TY - JOUR
T1 - Auranofin-Associated Colitis and Eosinophilia
AU - MICHET, CLEMENT J.
AU - RAKELA, JORGE
AU - LUTHRA, HARVINDER S.
PY - 1987
Y1 - 1987
N2 - Gold compounds, often used in the treatment of rheumatoid arthritis, have been associated with gastrointestinal disturbances in some patients. Use of auranofin, an oral gold preparation, in a 50-year-old woman with rheumatoid arthritis resulted in diarrhea, abdominal tenderness, nausea, and vomiting, which persisted despite discontinuation of auranofin therapy. The presumptive diagnosis was gold-induced colitis and eosinophilia. Administration of cromolyn sodium provided relief. Although this complication may be rare, evolving bowel symptoms in patients receiving auranofin demand prompt attention.
AB - Gold compounds, often used in the treatment of rheumatoid arthritis, have been associated with gastrointestinal disturbances in some patients. Use of auranofin, an oral gold preparation, in a 50-year-old woman with rheumatoid arthritis resulted in diarrhea, abdominal tenderness, nausea, and vomiting, which persisted despite discontinuation of auranofin therapy. The presumptive diagnosis was gold-induced colitis and eosinophilia. Administration of cromolyn sodium provided relief. Although this complication may be rare, evolving bowel symptoms in patients receiving auranofin demand prompt attention.
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U2 - 10.1016/S0025-6196(12)61885-0
DO - 10.1016/S0025-6196(12)61885-0
M3 - Article
C2 - 3807438
AN - SCOPUS:0023113285
SN - 0025-6196
VL - 62
SP - 142
EP - 144
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 2
ER -