Atypical squamous cells

Fadi W. Abdul-Karim, Celeste N. Powers, Jonathan S. Berek, Mark E. Sherman, Sana O. Tabbara, Mary K. Sidawy

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

The TBS category of “atypical squamous cells (ASC)” derives from the concept that a significant number of cases show changes that, while abnormal, are morphologically insufficient for a definitive interpretation of either LSIL or HSIL. ASC is the most common abnormality reported on cervical cytology specimens. These equivocal specimens have a higher risk for follow-up findings of SIL than do negative cases and therefore it is important to include the ASC category in the Bethesda reporting system to maintain the sensitivity of the Pap test. In Bethesda 2014, ASC continues to be further subdivided into “Atypical squamous cells – undetermined significance (ASC-US)” and “Atypical squamous cells – a high grade squamous intraepithelial lesion cannot be excluded (ASC-H).” ASC-US comprises the predominance of ASC cases, and is broadly defined as those cases showing features suggestive of LSIL. ASC-H represents only a small minority of cases and includes cases suggestive of HSIL. This conceptual scheme is consistent with the dichotomous categorization of the more definitive categories of LSIL and HSIL, and relates to our current understanding of HPV biology and cervical carcinogenesis. This chapter includes numerous examples of each ASC entity and many of the reactive changes from which it should be distinguished.

Original languageEnglish (US)
Title of host publicationThe Bethesda System for Reporting Cervical Cytology
Subtitle of host publicationDefinitions, Criteria, and Explanatory Notes
PublisherSpringer International Publishing
Pages103-134
Number of pages32
ISBN (Electronic)9783319110745
ISBN (Print)9783319110738
DOIs
StatePublished - Jan 1 2015

Fingerprint

Atypical Squamous Cells of the Cervix
Epithelial Cells
Cytology
Papanicolaou Test
Cell Biology
Carcinogenesis
Squamous Intraepithelial Lesions of the Cervix

Keywords

  • ASC-H
  • ASC-US
  • Cervix
  • Cytology atypical squamous cells
  • HPV triage
  • Reporting

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Abdul-Karim, F. W., Powers, C. N., Berek, J. S., Sherman, M. E., Tabbara, S. O., & Sidawy, M. K. (2015). Atypical squamous cells. In The Bethesda System for Reporting Cervical Cytology: Definitions, Criteria, and Explanatory Notes (pp. 103-134). Springer International Publishing. https://doi.org/10.1007/978-3-319-11074-5_4

Atypical squamous cells. / Abdul-Karim, Fadi W.; Powers, Celeste N.; Berek, Jonathan S.; Sherman, Mark E.; Tabbara, Sana O.; Sidawy, Mary K.

The Bethesda System for Reporting Cervical Cytology: Definitions, Criteria, and Explanatory Notes. Springer International Publishing, 2015. p. 103-134.

Research output: Chapter in Book/Report/Conference proceedingChapter

Abdul-Karim, FW, Powers, CN, Berek, JS, Sherman, ME, Tabbara, SO & Sidawy, MK 2015, Atypical squamous cells. in The Bethesda System for Reporting Cervical Cytology: Definitions, Criteria, and Explanatory Notes. Springer International Publishing, pp. 103-134. https://doi.org/10.1007/978-3-319-11074-5_4
Abdul-Karim FW, Powers CN, Berek JS, Sherman ME, Tabbara SO, Sidawy MK. Atypical squamous cells. In The Bethesda System for Reporting Cervical Cytology: Definitions, Criteria, and Explanatory Notes. Springer International Publishing. 2015. p. 103-134 https://doi.org/10.1007/978-3-319-11074-5_4
Abdul-Karim, Fadi W. ; Powers, Celeste N. ; Berek, Jonathan S. ; Sherman, Mark E. ; Tabbara, Sana O. ; Sidawy, Mary K. / Atypical squamous cells. The Bethesda System for Reporting Cervical Cytology: Definitions, Criteria, and Explanatory Notes. Springer International Publishing, 2015. pp. 103-134
@inbook{8277d3104f644218a900ec155a01a9c3,
title = "Atypical squamous cells",
abstract = "The TBS category of “atypical squamous cells (ASC)” derives from the concept that a significant number of cases show changes that, while abnormal, are morphologically insufficient for a definitive interpretation of either LSIL or HSIL. ASC is the most common abnormality reported on cervical cytology specimens. These equivocal specimens have a higher risk for follow-up findings of SIL than do negative cases and therefore it is important to include the ASC category in the Bethesda reporting system to maintain the sensitivity of the Pap test. In Bethesda 2014, ASC continues to be further subdivided into “Atypical squamous cells – undetermined significance (ASC-US)” and “Atypical squamous cells – a high grade squamous intraepithelial lesion cannot be excluded (ASC-H).” ASC-US comprises the predominance of ASC cases, and is broadly defined as those cases showing features suggestive of LSIL. ASC-H represents only a small minority of cases and includes cases suggestive of HSIL. This conceptual scheme is consistent with the dichotomous categorization of the more definitive categories of LSIL and HSIL, and relates to our current understanding of HPV biology and cervical carcinogenesis. This chapter includes numerous examples of each ASC entity and many of the reactive changes from which it should be distinguished.",
keywords = "ASC-H, ASC-US, Cervix, Cytology atypical squamous cells, HPV triage, Reporting",
author = "Abdul-Karim, {Fadi W.} and Powers, {Celeste N.} and Berek, {Jonathan S.} and Sherman, {Mark E.} and Tabbara, {Sana O.} and Sidawy, {Mary K.}",
year = "2015",
month = "1",
day = "1",
doi = "10.1007/978-3-319-11074-5_4",
language = "English (US)",
isbn = "9783319110738",
pages = "103--134",
booktitle = "The Bethesda System for Reporting Cervical Cytology",
publisher = "Springer International Publishing",

}

TY - CHAP

T1 - Atypical squamous cells

AU - Abdul-Karim, Fadi W.

AU - Powers, Celeste N.

AU - Berek, Jonathan S.

AU - Sherman, Mark E.

AU - Tabbara, Sana O.

AU - Sidawy, Mary K.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The TBS category of “atypical squamous cells (ASC)” derives from the concept that a significant number of cases show changes that, while abnormal, are morphologically insufficient for a definitive interpretation of either LSIL or HSIL. ASC is the most common abnormality reported on cervical cytology specimens. These equivocal specimens have a higher risk for follow-up findings of SIL than do negative cases and therefore it is important to include the ASC category in the Bethesda reporting system to maintain the sensitivity of the Pap test. In Bethesda 2014, ASC continues to be further subdivided into “Atypical squamous cells – undetermined significance (ASC-US)” and “Atypical squamous cells – a high grade squamous intraepithelial lesion cannot be excluded (ASC-H).” ASC-US comprises the predominance of ASC cases, and is broadly defined as those cases showing features suggestive of LSIL. ASC-H represents only a small minority of cases and includes cases suggestive of HSIL. This conceptual scheme is consistent with the dichotomous categorization of the more definitive categories of LSIL and HSIL, and relates to our current understanding of HPV biology and cervical carcinogenesis. This chapter includes numerous examples of each ASC entity and many of the reactive changes from which it should be distinguished.

AB - The TBS category of “atypical squamous cells (ASC)” derives from the concept that a significant number of cases show changes that, while abnormal, are morphologically insufficient for a definitive interpretation of either LSIL or HSIL. ASC is the most common abnormality reported on cervical cytology specimens. These equivocal specimens have a higher risk for follow-up findings of SIL than do negative cases and therefore it is important to include the ASC category in the Bethesda reporting system to maintain the sensitivity of the Pap test. In Bethesda 2014, ASC continues to be further subdivided into “Atypical squamous cells – undetermined significance (ASC-US)” and “Atypical squamous cells – a high grade squamous intraepithelial lesion cannot be excluded (ASC-H).” ASC-US comprises the predominance of ASC cases, and is broadly defined as those cases showing features suggestive of LSIL. ASC-H represents only a small minority of cases and includes cases suggestive of HSIL. This conceptual scheme is consistent with the dichotomous categorization of the more definitive categories of LSIL and HSIL, and relates to our current understanding of HPV biology and cervical carcinogenesis. This chapter includes numerous examples of each ASC entity and many of the reactive changes from which it should be distinguished.

KW - ASC-H

KW - ASC-US

KW - Cervix

KW - Cytology atypical squamous cells

KW - HPV triage

KW - Reporting

UR - http://www.scopus.com/inward/record.url?scp=84941642371&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941642371&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-11074-5_4

DO - 10.1007/978-3-319-11074-5_4

M3 - Chapter

AN - SCOPUS:84941642371

SN - 9783319110738

SP - 103

EP - 134

BT - The Bethesda System for Reporting Cervical Cytology

PB - Springer International Publishing

ER -