Atypical Shigella boydii 13 encodes virulence factors seen in attaching and effacing Escherichia coli

Laura L. Walters, Erica L. Raterman, Thomas Grys, Rodney A. Welch

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Enterohemorrhagic Escherichia coli (EHEC) is a foodborne pathogen that causes watery diarrhea and hemorrhagic colitis. In this study, we identified StcE, a secreted zinc metalloprotease that contributes to intimate adherence of EHEC to host cells, in culture supernatants of atypical Shigella boydii 13 (Shigella B13) strains. Further examination of the Shigella B13 strains revealed that this cluster of pathogens does not invade but forms pedestals on HEp-2 cells similar to EHEC and enteropathogenic E. coli. This study also demonstrates that atypical Shigella B13 strains are more closely related to attaching and effacing E. coli and that their evolution recapitulates the progression from ancestral E. coli to EHEC.

Original languageEnglish (US)
Pages (from-to)20-25
Number of pages6
JournalFEMS Microbiology Letters
Volume328
Issue number1
DOIs
StatePublished - Mar 1 2012
Externally publishedYes

Fingerprint

Shigella boydii
Enterohemorrhagic Escherichia coli
Virulence Factors
Escherichia coli
Enteropathogenic Escherichia coli
Metalloproteases
Colitis
Zinc
Diarrhea
Cell Culture Techniques

Keywords

  • Attaching and effacing lesions
  • E. coli O157:H7
  • Shigella boydii 13
  • StcE

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

Cite this

Atypical Shigella boydii 13 encodes virulence factors seen in attaching and effacing Escherichia coli. / Walters, Laura L.; Raterman, Erica L.; Grys, Thomas; Welch, Rodney A.

In: FEMS Microbiology Letters, Vol. 328, No. 1, 01.03.2012, p. 20-25.

Research output: Contribution to journalArticle

Walters, Laura L. ; Raterman, Erica L. ; Grys, Thomas ; Welch, Rodney A. / Atypical Shigella boydii 13 encodes virulence factors seen in attaching and effacing Escherichia coli. In: FEMS Microbiology Letters. 2012 ; Vol. 328, No. 1. pp. 20-25.
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