Atypical Shigella boydii 13 encodes virulence factors seen in attaching and effacing Escherichia coli

Laura L. Walters; Erica L. Raterman; Thomas E. Grys; Rodney A. Welch

doi:10.1111/j.1574-6968.2011.02469.x

Atypical Shigella boydii 13 encodes virulence factors seen in attaching and effacing Escherichia coli

Laura L. Walters, Erica L. Raterman, Thomas E. Grys, Rodney A. Welch

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Enterohemorrhagic Escherichia coli (EHEC) is a foodborne pathogen that causes watery diarrhea and hemorrhagic colitis. In this study, we identified StcE, a secreted zinc metalloprotease that contributes to intimate adherence of EHEC to host cells, in culture supernatants of atypical Shigella boydii 13 (Shigella B13) strains. Further examination of the Shigella B13 strains revealed that this cluster of pathogens does not invade but forms pedestals on HEp-2 cells similar to EHEC and enteropathogenic E. coli. This study also demonstrates that atypical Shigella B13 strains are more closely related to attaching and effacing E. coli and that their evolution recapitulates the progression from ancestral E. coli to EHEC.

Original language	English (US)
Pages (from-to)	20-25
Number of pages	6
Journal	FEMS Microbiology Letters
Volume	328
Issue number	1
DOIs	https://doi.org/10.1111/j.1574-6968.2011.02469.x
State	Published - Mar 2012

Keywords

Attaching and effacing lesions
E. coli O157:H7
Shigella boydii 13
StcE

ASJC Scopus subject areas

Microbiology
Molecular Biology
Genetics

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10.1111/j.1574-6968.2011.02469.x

Cite this

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abstract = "Enterohemorrhagic Escherichia coli (EHEC) is a foodborne pathogen that causes watery diarrhea and hemorrhagic colitis. In this study, we identified StcE, a secreted zinc metalloprotease that contributes to intimate adherence of EHEC to host cells, in culture supernatants of atypical Shigella boydii 13 (Shigella B13) strains. Further examination of the Shigella B13 strains revealed that this cluster of pathogens does not invade but forms pedestals on HEp-2 cells similar to EHEC and enteropathogenic E. coli. This study also demonstrates that atypical Shigella B13 strains are more closely related to attaching and effacing E. coli and that their evolution recapitulates the progression from ancestral E. coli to EHEC.",

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AU - Welch, Rodney A.

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AB - Enterohemorrhagic Escherichia coli (EHEC) is a foodborne pathogen that causes watery diarrhea and hemorrhagic colitis. In this study, we identified StcE, a secreted zinc metalloprotease that contributes to intimate adherence of EHEC to host cells, in culture supernatants of atypical Shigella boydii 13 (Shigella B13) strains. Further examination of the Shigella B13 strains revealed that this cluster of pathogens does not invade but forms pedestals on HEp-2 cells similar to EHEC and enteropathogenic E. coli. This study also demonstrates that atypical Shigella B13 strains are more closely related to attaching and effacing E. coli and that their evolution recapitulates the progression from ancestral E. coli to EHEC.

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Atypical Shigella boydii 13 encodes virulence factors seen in attaching and effacing Escherichia coli

Abstract

Keywords

ASJC Scopus subject areas

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