Atypical cutaneous γδ T cell proliferation with morphologic features of lymphoma but with clinical features and course of PLEVA or lymphomatoid papulosis

Rebecca King, Albert C. Yan, Debora R. Sekiguchi, John K. Choi

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Reactive lymphoid infiltrates of the skin composed predominantly of gamma-delta (γδ) T cells are not well described in the literature. Herein we report a case of an otherwise healthy 4-year-old male who presented with a waxing and waning papular rash characterized by small, discrete crusted papules spread across his trunk, face and extremities. Clinical evaluation revealed no evidence of systemic disease. Microscopic examination revealed a dermal, perivascular infiltrate of highly atypical lymphocytes with a γδ T cell phenotype, worrisome for primary cutaneous γδ T cell lymphoma. The clinical course, however, was that of a reactive condition and prompted consideration of a diagnosis of pityriasis lichenoides et varioliformis acuta (PLEVA) and lymphomatoid papulosis (LyP). In many ways, this case defies current classification schemes and seems to expand the spectrum of reactive γδ T cell infiltrates of the skin.

Original languageEnglish (US)
Pages (from-to)1012-1017
Number of pages6
JournalJournal of Cutaneous Pathology
Volume42
Issue number12
DOIs
StatePublished - Dec 1 2015
Externally publishedYes

Keywords

  • atypical features
  • CUTANEOUS LYMPHOMAS
  • hematopathology
  • T lymphocytes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology

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