Atypical carcinoid of the lung: A distinct clinicipathologic entity

T. H. Grote, W. R. Macon, B. Davis, F. A. Greco, D. H. Johnson

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Eleven cases of atypical carcinoid (AC) of the lung were identified during an eight-year period. Their clinical features and treatment responses were contrasted with our experience at Vanderbilt with small cell lung cancer (SCLC) and a literature review of typical bronchial carcinoids (TC). Clinically, there were no features to distinguish AC from TC except for age at diagnosis (59 vs 49 years). Atypical carcinoid was similar to SCLC with respect to many clinical features, although female sex, absence of smoking history and localized disease at presentation were more common in AC. Pathologically, these tumors were distinguished by cellular atypia, necrosis, architectural disorder, or increased mitotic rate in the presence of a recognizable carcinoid pattern. Immunoperoxidase staining revealed no difference between AC and TC or SCLC. Atypical carcinoid of the lung represents a distinct clinicopathologic disease.

Original languageEnglish (US)
Pages (from-to)370-375
Number of pages6
JournalChest
Volume93
Issue number2
StatePublished - 1988
Externally publishedYes

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Carcinoid Tumor
Lung
Small Cell Lung Carcinoma
Necrosis
Smoking
History
Staining and Labeling

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Grote, T. H., Macon, W. R., Davis, B., Greco, F. A., & Johnson, D. H. (1988). Atypical carcinoid of the lung: A distinct clinicipathologic entity. Chest, 93(2), 370-375.

Atypical carcinoid of the lung : A distinct clinicipathologic entity. / Grote, T. H.; Macon, W. R.; Davis, B.; Greco, F. A.; Johnson, D. H.

In: Chest, Vol. 93, No. 2, 1988, p. 370-375.

Research output: Contribution to journalArticle

Grote, TH, Macon, WR, Davis, B, Greco, FA & Johnson, DH 1988, 'Atypical carcinoid of the lung: A distinct clinicipathologic entity', Chest, vol. 93, no. 2, pp. 370-375.
Grote TH, Macon WR, Davis B, Greco FA, Johnson DH. Atypical carcinoid of the lung: A distinct clinicipathologic entity. Chest. 1988;93(2):370-375.
Grote, T. H. ; Macon, W. R. ; Davis, B. ; Greco, F. A. ; Johnson, D. H. / Atypical carcinoid of the lung : A distinct clinicipathologic entity. In: Chest. 1988 ; Vol. 93, No. 2. pp. 370-375.
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