TY - JOUR
T1 - Attention and visual dysfunction in Parkinson's disease
AU - Botha, Hugo
AU - Carr, Jonathan
N1 - Funding Information:
Dr Carr receives funding from the National Research Foundation of South Africa .
PY - 2012/7
Y1 - 2012/7
N2 - Visual processing extends from the retinal level to the ventral temporal lobe, and is modified by top-down and bottom-up processing. Complex visual hallucinations (VH) are commonly a feature of disorders which affect temporal lobe structures, frequently in association with impairment of ascending monoaminergic pathways. When Parkinson's disease (PD) is associated with VH, pathological changes characteristically affect the temporal lobes, a finding which is recapitulated by imaging findings. However, a major association of VH is with cognitive decline, and this is typically linked to deficits in attention and working memory, both of which are modulated by dopamine. Similarly, dopamine plays a crucial role in the function of prefrontal cortex, in addition to controlling access to consciousness via gating mechanisms that are dependent on the basal ganglia.
AB - Visual processing extends from the retinal level to the ventral temporal lobe, and is modified by top-down and bottom-up processing. Complex visual hallucinations (VH) are commonly a feature of disorders which affect temporal lobe structures, frequently in association with impairment of ascending monoaminergic pathways. When Parkinson's disease (PD) is associated with VH, pathological changes characteristically affect the temporal lobes, a finding which is recapitulated by imaging findings. However, a major association of VH is with cognitive decline, and this is typically linked to deficits in attention and working memory, both of which are modulated by dopamine. Similarly, dopamine plays a crucial role in the function of prefrontal cortex, in addition to controlling access to consciousness via gating mechanisms that are dependent on the basal ganglia.
KW - Attention
KW - Dopamine
KW - Parkinson's disease
KW - Visual hallucinations
KW - Working memory
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U2 - 10.1016/j.parkreldis.2012.03.004
DO - 10.1016/j.parkreldis.2012.03.004
M3 - Article
C2 - 22503538
AN - SCOPUS:84862221654
SN - 1353-8020
VL - 18
SP - 742
EP - 747
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
IS - 6
ER -