Atrial natriuretic peptide, volume and blood pressure regulation during exchange transfusion of the neonates.

Andras Khoor, T. Tulassay, W. Rascher, M. Bald, T. Machay, J. Kiszel, S. Csömör

Research output: Contribution to journalArticlepeer-review

Abstract

Plasma concentrations of atrial natriuretic peptide (ANP) and hemodynamic parameters were investigated in five premature infants undergoing exchange transfusion. Baseline values of ANP were elevated being 51.7 +/- 21.2 fmol/ml. Volume depletion by withdrawal of 10 ml blood did not cause changes in systolic blood pressure (79.4 +/- 4.3 vs 71.4 +/- 5.6 mmHg) and heart rate (115 +/- 5.2 vs 115 +/- 2.4 l/min). ANP levels in plasma remained unaltered (53.4 +/- 24.9 fmol/ml). Volume load of 10 ml blood transfusion increased central venous pressure by 33 per cent and ANP concentration in the plasma nearly by 30 per cent, while heart rate and blood pressure remained unchanged. Our data indicated that the heart of premature infant responds to acute volume load by increased ANP-release, while volume depletion seems not to influence hormone regulation.

Original languageEnglish (US)
Pages (from-to)191-199
Number of pages9
JournalActa Paediatrica Hungarica
Volume30
Issue number2
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Atrial natriuretic peptide, volume and blood pressure regulation during exchange transfusion of the neonates.'. Together they form a unique fingerprint.

Cite this